The Effect Of Alcohol Consumption On Lipid Parameters

Authors

  • Stella Ngozi Cookey Rivers State University Teaching Hospital/ Rivers State University
  • Victoria Eno Gomba Rivers State University Teaching Hospital/ Rivers State University
  • Ernest O Nwazor Rivers State University Teaching Hospital

DOI:

https://doi.org/10.60787/tnhj.v22i2.578

Keywords:

Alcohol, Cholesterol, LDL, HDL, Triglycerides, Ethanol

Abstract

Background: Though views of authors vary regarding moderate alcohol consumption, they however agree that excessive alcohol consumption has a deleterious effect on the cardiovascular system. Dyslipidaemia has been implicated as a risk factor for cardiovascular disease and mild to moderate alcohol consumption is said to be cardioprotective, though still a subject of debate. The study compared cholesterol parameters with daily alcohol consumption in residents of Rumuekini community.

Methods: Forty-one male subjects had their blood samples collected after an overnight fast. Information on their occupation, symptoms and history of alcohol consumption were obtained using a questionnaire. The quantity of alcohol was assessed and the study population was divided into mild, moderate and severe based on amount of daily alcohol consumption.

Results: Forty-one participants completed the study, age ranged from 19 to 91years with mean age of 34.49 ± 17.25yrs, mean systolic blood pressure of 128.10 ± 21.92mmHg,  mean diastolic blood pressure of 77.20 ± 14.87mmHg and mean daily alcohol consumption was  74.24 ± 43.34g/day. The mean total cholesterol was 181.53 ± 41.43mg/dl, mean triglyceride was 139.84± 40.18mg/dl and mean low density lipoprotein was 79.34 ± 26.10 mg/dl while mean high density lipoprotein was 62.75 ± 13.54mg/dl. Excessive alcohol consumption was associated with lower total cholesterol, LDL and TG while moderate alcohol consumption was associated with higher HDL level.

Conclusion: This study noted that alcohol generally reduced total cholesterol in a linear fashion, however this was at a summed effect of reducing LDL, increasing HDL and reducing TG.

Downloads

Download data is not yet available.

Author Biographies

Stella Ngozi Cookey, Rivers State University Teaching Hospital/ Rivers State University

Department of Internal Medicine, Consultant Cardiologist and Lecturer 1

Victoria Eno Gomba, Rivers State University Teaching Hospital/ Rivers State University

Department of Internal Medicine, Consultant Endocrinologist/Lecturer 1

Ernest O Nwazor, Rivers State University Teaching Hospital

Department of Internal Medicine, Consultant Neurologist

References

. The Impact of Alcohol on the Cardiovascular Health Myths and Measures, https://world-heart-federation.org/wp-content/uploads/WHF-Policy-Brief Alcohol.pdf,2022/01/20.[accessed on 20/01/2022]

. Gaziano JM, Buring JE, Breslow JL, Goldhaber SZ, Rosner B, VanDenburgh M, Willett W, Hennekens CH. Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. N Engl J Med.. 1993;329:1829-1834.

. Gordon T, Ernst N, Fisher M, Rifkind BM. Alcohol and high-density lipoprotein cholesterol. Circulation. 1981;64(suppl III): III-63-III-67.

. Hulley SB, Gordon S. Alcohol and high-density lipoprotein cholesterol: causal inference from diverse study designs. Circulation. 1981;64(suppl III):III-57-III-63.

. Haskell WL, Camargo C Jr, Williams PT, Vranizan KM, Krauss RM, Lindgren FT, Wood PD. The effect of cessation and resumption of moderate alcohol intake on serum high-density-lipoprotein subfractions: a controlled study. N Engl J Med.. 1984;310:805-810.

. Suh I, Shaten BJ, Cutler JA, Kuller LH, for the Multiple Risk Factor Intervention Trial research group. Alcohol use and mortality from coronary heart disease: the role of high-density lipoprotein cholesterol. Ann Intern Med.. 1992;116:881-887.

. Lakshman R, Garige M, Gong M, Leckey L, Varatharajalu R, Zakhari S. Is alcohol beneficial or harmful for cardioprotection? Genes Nutr. 2010 Jun;5(2):111-20. doi: 10.1007/s12263-009-0161-2. PMID: 20012900; PMCID: PMC2885161.

. Hines LM, Rimm EBModerate alcohol consumption and coronary heart disease: a reviewPostgraduate Medical Journal 2001;77:747-752.

. Berger S, Raman G, Vishwanathan R, Jacques PF, Johnson EJ. Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis. Am J Clin Nutr. 2015 Aug;102(2):276-94. doi: 10.3945/ajcn.114.100305. Epub 2015 Jun 24. PMID: 26109578.

. Sato M, Maulik N, Das DK. Cardioprotection with alcohol: role of both alcohol and polyphenolic antioxidants. Ann N Y Acad Sci. 2002 May;957:122-35. doi: 10.1111/j.1749-6632.2002.tb 02911.x. PMID: 12074967.

. Cui J, Tosaki A, Bertelli AA, Bertelli A, Maulik N, Das DK. Cardioprotection with white wine. Drugs Exp Clin Res. 2002;28(1):1-10. PMID: 12073762.

. Nigam PK. Serum Lipid Profile: Fasting or Non-fasting? Indian J Clin Biochem. 2011 Jan;26(1):96-7. doi: 10.1007/s12291-010-0095-x. Epub 2010 Dec 29. PMID: 22211025; PMCID: PMC3068759.

. Schaefer EJ, Anthanont P, Asztalos BF. High-density lipoprotein metabolism, composition, function, and deficiency. Curr Opin Lipidol. 2014 Jun;25(3):194-9. doi: 10.1097/MOL.0000000000000074. PMID: 24785961; PMCID: PMC5489068.

. Kosmas CE, DeJesus E, Rosario D, Vittorio TJ. CETP Inhibition: Past Failures and Future Hopes. Clin Med Insights Cardiol. 2016 Mar 13;10:37-42. doi: 10.4137/CMC.S32667. PMID: 26997876; PMCID: PMC4790583.

. Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet.. 1992;339:1523-1526.

. Brown L, Kroon PA, Das DK, Das S, Tosaki A, Chan V, Singer MV, Feick P. The biological responses to resveratrol and other polyphenols from alcoholic beverages. Alcohol Clin Exp Res. 2009 Sep;33(9):1513-23. doi: 10.1111/j.1530-0277.2009.00989.x. Epub 2009 Jun 10. PMID: 19519720; PMCID: PMC2782726.

. Ridker PM, Vaughan DE, Stampfer MJ, Glynn RJ, Hennekens CH. Alcohol Consumption and Tissue-Type Plasminogen Activator Reply. JAMA. 1995;273(18):1416–1417.doi:10.1001/jama.1995.03520420028018

. Ridker PM, Vaughan DE, Stampfer MJ, Glynn RJ, Hennekens CH. Association of moderate alcohol consumption and plasma concentration of endogenous tissue-type plasminogen activator. JAMA. 1994 Sep 28;272(12):929-33. doi: 10.1001/jama.1994.03520120039028. PMID: 7794308.

. Das, Dipak K. Dr., "Alcohol in Moderation, Cardioprotection and Neuroprotection : Epidemiological Considerations and Mechanistic Studies" (2009). UCHC Articles - Research. 3. https://opencommons.uconn.edu/uchcres_articles/3

. Alcohol by Volume: Beer, Wine and Liquor American Addiction Centers. https://www.alcohol.org/statistics-information/abv/{Accessed on 27/02/2022]

. Obio-Akpor, https://en.wikipedia.org/wiki/Obio-Akpor [accessed on 27/02/2022]

. Diana Dinescu, University of Virginiahttps://news.virginia.edu/content/does-marriage-affect-drinking-new-study-provides-insights

. Ellison, Christopher G., et al. “Gender, Marital Status, and Alcohol Behavior: The Neglected Role of Religion.” Journal for the Scientific Study of Religion, vol. 47, no. 4, [Society for the Scientific Study of Religion, Wiley], 2008, pp. 660–77, http://www.jstor.org/stable/20486961.

. Booranasuksakul U, Singhato A, Rueangsri N, Prasertsri P. Association between Alcohol Consumption and Body Mass Index in University Students. Asian Pac Isl Nurs J. 2019;4(1):57-65. doi: 10.31372/20190401.1035. PMID: 31037273; PMCID: PMC6484200.

. Mary A. Nies, Linman Sun, Donna Kazemi, Amy Carriker, Jacek Dmochowski, "Relationship of Body Mass Index to Alcohol Consumption in College Freshmen", The Scientific World Journal, vol. 2012, Article ID 849018, 4 pages, 2012. https://doi.org/10.1100/2012/849018

Downloads

Published

2022-06-30

How to Cite

Cookey, S. N., Gomba, V. E., & Nwazor, E. O. (2022). The Effect Of Alcohol Consumption On Lipid Parameters. The Nigerian Health Journal, 22(2). https://doi.org/10.60787/tnhj.v22i2.578
Abtract Views | PDF Download | EPUB Download: 324 / 21

Similar Articles

1 2 3 > >> 

You may also start an advanced similarity search for this article.