Cycloserine Induced Psychosis among Patient's on Second Line Treatment for Drug Resistant Tuberculosis in Bauchi and Port Harcourt, Nigeria
DOI:
https://doi.org/10.60787/tnhj.v15i3.222Keywords:
Cycloserine, Multi-drug resistant tuberculosis, Adverse Drug Reactions, Psychosis, NigeriaAbstract
Background: Adverse effects from second line drugs used in MDRTB treatment include neuropsychiatric effects which are usually very significant as they may cause anxiety and lead to default and poor adherence by patients if quick recognition and intervention is not available. This case series aims highlight the occurrence of cycloserine related psychosis among patient on treatment for MDR-TB in Nigeria^ with the objective of promoting adequate evaluation and quick response and treatment to this important ADR.
Method: The case records of 3 patients from two MDR-TB in-patient treatment centers in Nigeria and a review of the existing literature was utilized. Results
Results: An association was found with the use of Cycloserine and development of Psychosis during the management of these patients with MDR-TB. Early recognition and quick treatment is required to ensure treatment continuation and resolution of the ADR.
Conclusion: Patients with MDR-TB on Cycloserine containing CAT IV regimen should be monitored closely for neuropsychiatric side effects for early diagnosis, prevention and treatment.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2016 The Nigerian Health Journal
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The Journal is owned, published and copyrighted by the Nigerian Medical Association, River state Branch. The copyright of papers published are vested in the journal and the publisher. In line with our open access policy and the Creative Commons Attribution License policy authors are allowed to share their work with an acknowledgement of the work's authorship and initial publication in this journal.
This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author.
The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations. While the advice and information in this journal are believed to be true and accurate on the date of its going to press, neither the authors, the editors, nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein.
TNHJ also supports open access archiving of articles published in the journal after three months of publication. Authors are permitted and encouraged to post their work online (e.g, in institutional repositories or on their website) within the stated period, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). All requests for permission for open access archiving outside this period should be sent to the editor via email to editor@tnhjph.com.
