An Overview of Chronic Obstructive Pulmonary Disease (COPD): Epidemiology and Pathogenesis

Authors

  • Victor Aniedi Umoh Department of Internal Medicine, College of Health Sciences, University of Uyo, Uyo

DOI:

https://doi.org/10.60787/tnhj.v12i3.135

Keywords:

COPD, Epidemiology, Pathogenesis

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) is one of the most common chronic respiratory diseases which contribute significantly to the burden of non-communicable diseases. With the increasing prevalence of COPD in developing countries a good knowledge of disease burden and process is essential.

Methods: Review of the available literature on the subject was done through Medline and Google search utilising the following keywords COPD; epidemiology; pathogenesis and management.

Result: COPD which is increasing in prevalence has varied pathogenetic mechanisms which are influenced by both intrinsic and extrinsic environmental promoters.

Conclusion: The prevalence of COPD is increasing especially in developing countries. The pathogenesis is multifactorial and current understanding provides insights that are expected to improve on treatment and outcome.

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References

Celli BR, MacNee W, Agusti A, Anzueto A, Berg B, Buist AS et. al. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004; 23: 932–946

AmericanThoracicSociety.Chronicbronchitis,asthmaandpulmonaryemphysema: a statement by the Committee onDiagnosticStandardsforNontuberculous Respiratory Diseases. Am Rev Respir Dis 1962; 85: 762–768.

Snider GL, Kleinerman J, Thurlbeck WM, Bengali ZK. The definition of emphysema: report of a National Heart, Lung and Blood Institute, Division of Lung Diseases,Workshop. Am Rev Respir Dis 1985; 132: 182–185.Page 60COPD: Epidemiology and Pathogenesis — Umoh V. A.The Nigerian Health Journal, Vol. 12, No 3, July — September, 2012

Anthonisen NR, Connet JE, murray RP. Smoking and lung function of lung health study participants after 11 years. Am J Respir Crit Care Med. 2002;166:675-9

Løkke A, Lange P, Scharling H, Fabricius P, Vestbo J. Developing COPD: a 25 year follow up study of the general population. Thorax 2006;61:935–939.

ATS: Cigarette smoking and health. Am J Respir Crit Care Med 1996, 153(2):861-865

BurrowsB,KnudsonRJ,ClineMG,Lebowitz MD: Quantitative relationship between cigarette smoking and ventilator function. Am Rev Resp Dis 1977, 115:195-205.

Coultas DB, Hanis CL, Howard CA, Skipper BJ, Samet JM. Heritability of ventilatory function in smoking and nonsmoking New Mexico Hispanics. Am Rev Respir Dis 1991, 144(4):770-775.

Larson RK, Barman ML. The familial occurrenceofchronicobstructivepulmonarydisease.AnnInternMed1965;63: 1001–8.

Lebowitz MD, Knudson RJ, Burrows B. Family aggregation of pulmonary function measurements. Am Rev Respir Dis 1984; 129:8–11.

Kueppers F, Miller RD, Gordon H, Hepper NG,Offord K. Familial prevalenceof chronic obstructive pulmonary disease in a matchedpairstudy.AmJMed1977;63:336–42.

Khoury MJ, Beaty TH, Newill CA, Bryant S, CohenBH.Genetic-environmentalinteractions in chronic airways obstruction. Int J Epidemiol 1986;15:65–72.

Redline S, Tishler PV, Rosner B, Lewitter FI, Vandenburgh M, Weiss ST, Speizer FE. Genotypic and phenotypic similarities in pulmonaryfunctionamongfamilymembersofadultmonozygoticanddizygotic twins. Am J Epidemiol 1989, 129(4):827-836.

Tager I, Tishler PV, Rosner B, Speizer FE, Litt M. Studies of the familial aggregation of chronic bronchitis and obstructive airways disease. Int J Epidemiol 1978;7:55–62.

Sandford AJ, Weir TD, Pare P. Genetic risk factors for chronic obstructive pulmonary disease. Eur Respir J 1997; 10: 1380–1391.

Lindmark B, Svenonius E, Eriksson S. Heterozygous α1-antichymotrypsin and PiZ α1-antitrypsin deficiency. Prevalence and clinical spectrum in asthmatic children. Allergy:EurJAllergyClinImmunol1990;45:197–203.

Poller W, Faber JP, Scholz S, Weidinger S, Bartholome K, Olek K, et al. Mis-sense mutationofα1-antichymotrypsingeneassociatedwithchroniclungdisease.Lancet 1992;339:1538.

Poller W, Faber JP, Klobeck G, Olek K. Cloning of the human α2-macroglobulin gene and detection of mutations in two functional domains: the bait region and the thiolester site. Hum Genet 1992;88:313–9.

Hautamaki RD, Kobayashi DK, Senior RM, Shapiro SD. Requirement for macrophage elastaseforcigarettesmoke-inducedemphysemainmice.Science1997;277:2002–4.

D'Armiento J, Dalal SS, Okada Y, Berg RA, Chada K. Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema. Cell 1992;71:955–61.

Segura-Valdez L, Pardo A, Gaxiola M, Uhal BD, Becerril C, Selman M. Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD. Chest 2000;117:684–94.

Bentazzo MG, Gile LS, Bombieri C, Malerba G, Massobrio M, Pignatti PF, et al. alpha(1)-antitrypsin TaqI polymorphism andalpha(1)-antichymotrypsin mutations in patientswithobstructivepulmonarydisease.RespiratoryMedicine1999;93:648–54.

Sandford AJ, Chagani T, Weir TD, Paré PD. α1-antichymotrypsin mutations in patients with chronic obstructive pulmonary disease. Dis Markers 1998;13:257–60.

SmithCA,HarrisonDJ.Associationbetweenpolymorphismingeneformicrosomalepoxidehydrolaseandsusceptibilitytoemphysema.Lancet1997;350:630–3.

Yoshikawa M, Hiyama K, Ishioka S, Maeda H, Maeda A, Yamakido M. Microsomal epoxide hydrolase genotypes and chronic obstructive pulmonary disease in Japanese. J Mol Med 2000;5:49–53.

Yim JJ, Park GY, Lee CT, Kim YM, Han SK, Shim YS, et al. Genetic susceptibility to chronic obstructive pulmonary disease in Koreans: combined analysis of polymorphic genotypesformicrosomalepoxidehydrolase and glutathione S-transferase M1 and T1. Thorax 2000;55:121–5.

BaranovaH,PerriotJ,AlbuissonE,Ivaschenko T, Baranov VS, Hemery B, et al. Peculiarities of the GSTM1 0/0 genotype in French heavy smokers with various types of chronicbronchitis.HumGenet1997;99:822–6.

Cantlay AM, Lamb D, Gillooly M, Norrman J, Morrison D, Smith CAD, et al. Association between the CYP1A1 gene polymorphism and susceptibility to emphysema and lung cancer.JClinPathol:MolPathol1995;48:M210–4.

LadinaJoosa, Peter D. Paréa, Andrew J. Sandfordb. Genetic risk factors for chronic obstructive pulmonary disease. Swiss Med Wkly 2002 ; 132 : 27 – 37

Rijcken B, Scouten JP, Xu X, Rosner B, Weiss ST. Bronchial hyper-responsiveness to histamine is associated with accelerated decline of FEV1. Am J Respir Crit Care Med 1995;151:1377-1382

Lima JJ, Thomason DB, Mohamed MH, Eberle LV, Self TH, Johnson JA. Impact of geneticpolymorphismsofthebeta2-adrenergicreceptoronalbuterolbronchodilator pharmacodynamics. Clin Pharmacol Ther 1999;65:519–25.

Summerhill E, Leavitt SA, Gidley H, Parry R, Solway J, Ober C. Beta(2)-adrenergic receptor arg16/arg16 genotype is associated with reduced lung function, but not with asthma, in the Hutterites. Am J Respir Crit Care Med 2000;162:599–602.

Lange P, Parner J, Vestbo J, Jensen G, Schnohr P. A 15-year follow-up of ventilator function in adults with asthma. N Engl J Med 1998; 339: 1194–1200.

KestenS,ChapmanK.Physicianperceptions and management of COPD. Chest 1993;104:254–258.

Franks P, Clancy CM, Naumburg EH. Sex, access,andexcess.AnnInternMed1995;123:548–550.

Watson L, Vestbo J, Postma D, Decramer M, Rennard S, Kiri V et. al. Gender differences in the management and experiences of chronic obstructive pulmonary disease. Respir Med 2004;98:1207–1213.

Prescott E. Tobacco-related diseases: the role of gender. Dan Med Bull 2000; 47: 115–131.

Pauwels R, Buist A, Calverley P, Jenkins C, Hurd S. Global strategy for the diagnosis, management and prevention of chronic obstructivepulmonarydisease.NHLBI/WHO global initiative for chronic obstructive lung disease (GOLD) workshop summary. Am J Respir Crit Care Med 2001; 163: 1256–1276.

Kalandidi A, Trichopoulos D, Hatzakis A, Tzannes S, Saracci R. Passive smoking and chronic obstructive lung disease. Lancet 1987; 1325–1326.

Euler GL, Abbey DE, Magie AR, Hodkin JE. Chronic obstructive pulmonary disease symptom effects of long term cumulative exposuretoambientlevelsoftotalsuspended particulates and sulfur dioxide inCaliforniaSeventh-dayAdventistresidents. Arch Environ Health 1987; 42: 213–222.

Mannino DM, Homa DM, Akinbami LJ, Ford ES, Redd SC. Chronic obstructive pulmonary disease surveillance – United States, 1971–2000. MMWR 2002; 51: 1–16.

Prescott E, Vestbo J. Socioeconomic status and chronic obstructive pulmonary disease. Thorax 1999; 54: 737–741.

AntoJM,VermiereP,VestboJ.EpidermiologyofChronicObstructivePulmonary Disease. European Respiratory Journal 2001; 17:982-994.

Albalak R, Frisancho, Keeler GJ. Domestic biomass fuelcombustionand chronicbronchitis in two rural Bolivian villages. Thorax 1999;54;1004-1008.

Manuel J. The quest for fire: hazards of a daily struggle. Environ Health Perspect. 2003.111:A28–A33.

Burrows B. Knudson RJ, Lebowitz MD. The relationship of childhood respiratory illness to adult obstructive airway disease. Am Rev Respir Dis, 1977, 115, 751 - 760.

Paoletti P, Prediletto R, Carrozzi L, Viegi G, Di Pede F, Carmignani G, et al. Effects of childhoodandadolescence-adulthoodrespiratoryinfectionsinageneralpopulation. Eur Respir J 1989; 2: 428–436.

BurrowsB,KnudsonRJ,ClineMG,Lebowitz MD. A reexamination of risk factors for ventilatory impairment. Am Rev Respir Dis 1988; 138: 829–836.

Bates MN, Khalakdina A, Pai M, Chang L, Lessa F, Smith KR. Risk of Tuberculosis From Exposure to Tobacco Smoke: A Systematic Review and Meta-analysis. Arch Intern Med. 2007;167(4):335-342.

Lin HH, Ezzati M, Murray M. Tobacco smoke,indoorairpollutionandtuberculosis: a systematic review and meta-analysis.PLoSMed2007;4:e20.Downloaded on 18/01/2013 from http:// www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0040020

WorldHealthOrganizationGlobaltuberculosis control: epidemiology, strategy, financing.WHOreport2009.WHO/HTM/TB/ 2009.411. Geneva, World Health Organization, 2009.

Diaz PT, King ER, Wewers MD, Gadek JE, Neal D, Drake J et. al. Hiv infection increases susceptibility to smoking-induced emphysema.2000;117(5_suppl_1):285S-285S.

Crothers K, Butt AA, Gibert CL, Rodriguez-BarradasMC,CrystalS,JusticeAC.IncreasedCOPDamongHIV-positivecompared to HIV-negative veterans. Chest 2006; 130: 1326–1333.

Hallett WY, Martin CJ. The diffuse obstructive pulmonary syndrome in a tuberculosis sanatorium. I. Etiologic factors. Ann Intern Med1961;54:1146–1155

Ehrlich RI, White N, Norman R, Laubscher R, Steyn K, Lombard C, et.al. Predictors of chronic bronchitis in South African adults. Int J Tuberc Lung Dis 8(3):369–376

Menezes MB, Hallal PC, Perez-Padilla R, Jardim RB, Muin A, Lopez MV et.al. for the LatinAmericanProjectfortheInvestigation of Obstructive Lung Disease (PLATINO) Team. Tuberculosis and airflow obstruction: evidence from the PLATINO study in Latin America. Eur Respir J 2007; 30: 1180–1185

Lee SW, Kim YS, Kim D, Oh Y, Lee S. The RiskofObstructiveLungDiseasebyPrevious Pulmonary Tuberculosis in a Country withIntermediateBurden ofTuberculosis. J Korean Med Sci 2011; 26: 268-273

WillcoxPA,FergusonAD.Chronicobstructiveairwaysdiseasefollowingtreated pulmonarytuberculosis. RespirMed 1989;83:195–198.

Hnizdo E, Singh T, Churchyard G. Chronic pulmonary function impairment caused by initial and recurrent pulmonary tuberculosis following treatment. Thorax 2000;55:32–8.

Buist AS, Vollmer WM, Sullivan S, Weiss KB, Lee TA, Menezes AM. et al. The Burden of Lung Disease Initiative (BOLD): rationale and design. COPD 2005; 2: 277–83.

Buist AS, McBurnie MA, Vollmer WM, Gillespie S, Burney P, Mannino DM et. al. on behalfof the BOLD Collaborative Research Group. International variation in the prevalence of COPD (The BOLD Study):apopulation-basedprevalencestudy. Lancet 2007; 370: 741–50.

World health organisation (WHO); the global burden of disease: 2004 update. Available on 12/01/13 from http://www.who.int/healthinfo/global_burden_disease/GBD_report_2004update_full.pdf.

Medical Research Council Committee on theAetiologyofChronicBronchitis.Standardized questionnaires on respiratory symptoms. Br Med J 1960; 2: 1665.

Desalu OO, Adekoya AO, Ampitan BA. Increased risk of respiratory symptoms and chronic bronchitis in women using biomass fuels in Nigeria. J. Bras. Pneumol. 2010; 36(4) 441-446.

Fletcher C. Peto R, Tinker C, Speizer FE (1976). The natural history of chronic bronchitis and emphysema. An eight-year study of early chronic obstructive lung disease in working men in London. Oxford University Press, 37 Dover Street, London. W1X 4AH

Burrows B. Knudson RJ. Camilli AE. Lyle SK.LebowitzMD. The 'Horse-Racing Effect' and predicting decline in forced expiratory volume in one second from screening spirometry. Am Rev Respir Dis 1987;135:788-793.

Burrows, B. Airway obstructive diseases: pathogeneticmechanismsandnaturalhistories of the disorders. Med. Clin. North Am. 1990. 14:547-560.

Snider GL, Faling LJ, Rennard SI. Chronic bronchitis and emphysema. In: F. Murray and J. A. Nadel(editors). Textbook of Respiratory Medicine. W. B. Saunders, Philadelphia; 1994: 1342.

Reid L. Measurement of the bronchial mucous gland layer: a diagnostic yardstick in chronic bronchitis. Thorax 1960; 15; 132–141.

JamalK,CooneyTP,FleethamJA,ThurlbeckWM.Chronicbronchitis.Correlation of morphologic findings to sputum production and flow rates. Am Rev Respir Dis. 1984; 129: 719–722.

O'Shaughnessy TC, Ansari TW, Barnes NC, Jeffery PK. Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverserelationshipofCD8+Tlymphocytes with FEV1. Am J Respir Crit Care Med. 1997; 155: 852–857.

Pesci A, Balbi B, Majori M, Cacciani G, Bertacco S, Alciato P et al. Inflammatory cells and mediators in bronchial lavage of patientswithchronicobstructivepulmonary disease. Eur Respir J 1998; 12: 380–386.

Niewoehner DE, Kleinerman J, Rice DB. Pathologicchangesintheperipheralairways of young cigarette smokers. N Engl J Med 1974; 291: 755–758.

Cosio M, Ghezzo H, Hogg JC, Corbin R, Loveland M, Dosman J.et al. The relations between structural changes in small airways and pulmonary-function tests. N Engl J Med 1978; 298:1277–1281.

Saetta M, Di Stefano A, Turato G,Facchini FM , Corbino L, Mapp CE et al. CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 157: 822–826.

Rennard SI. Inflammationand repair processes in chronic obstructive pulmonary disease. Am J RespirCrit Care Med 1999; 160: S12–S16.

Lamb D, McLean A, Gillooly M, Warren PM, Gould GA, MacNee W. Relation between distal airspace size, bronchiolar attachments, and lung function. Thorax 1993; 48: 1012–1017.

Finkelstein R, Fraser RS, Ghezzo H, Cosio MG. Alveolar inflammation and its relation to emphysema in smokers. Am J Respir Crit Care Med 1995; 152: 1666–1672.

Wright JL, Lawson L, Pare PD,, Hooper RO, Peretz DI, Nelems JM et al. The structure and function of the pulmonary vasculature in mild chronic obstructive pulmonary disease. The effect of oxygen and exercise. Am Rev Respir Dis 1983; 128: 702–707.

Vinod Mishra. What do we know about health effects of smoke from solid fuel combustion? Population and health series. No. 117, January 2004. Download from (www.EastWestCenter.org) 24/12/2007

Riley DJ, Thakker-Varia S, Poiani GJ, Tozzi CA.VascularRemodeling.TheLung:Scientificfoundations.1589–1597. Philadelphia, Lippincott-Raven, 1977.

MacNeeW.Pathophysiologyofcorpulmonaleinchronicobstructivepulmonary disease. Part two. Am J Respir

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Published

2015-12-21

How to Cite

Umoh, V. A. (2015). An Overview of Chronic Obstructive Pulmonary Disease (COPD): Epidemiology and Pathogenesis. The Nigerian Health Journal, 12(3), 55. https://doi.org/10.60787/tnhj.v12i3.135
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