Medication Related Cutaneous Disorders in End Stage Renal Disease Patients in Lagos

Authors

  • Bolaji Otike-Odibi Department of Internal Medicine, University of Port-Harcourt Teaching Hospital, Port Harcourt
  • Olaitan Christiana Okunoye Department of Internal Medicine, University of Port-Harcourt Teaching Hospital, Port Harcourt

Keywords:

Cutaneous disorders, Medication use, ESRD/CKD

Abstract

Background: In End Stage Renal Disease (ESRD) patients, a wide range of cutaneous manifestations are present which may be due to the medications prescribed. Most patients' with ESRD are on numerous medications for their primary ailment, with transplant patients needing long term steroids and cytotoxics for allograft survival. The purpose of the study is to identify the medication related cutaneous disorders in End Stage Renal Disease patients and the causative drugs.

Methods: A simple random sampling technique was used to select 138 ESRD patients (GFR<15mls / min) from the Lagos University Teaching Hospital, Life Support and St Nicholas Hospital, Lagos, Nigeria as well as Renal transplant patients. Also 138 non-renal, non-hypertensive, non- diabetic patients from the medical wards of L. U.T.H, with Chronic Kidney disease stage 0, GFR > 90mls / min were used as controls. They were all examined for medication related disorders and list of drugs used collated.

Results: The ESRD patients consisted of seventy six (55%) on dialysis, fifty- two (38%) on conservative management and ten (7%) post-transplant.Medication related disorders included hypertrichosis due to cyclosporine and minoxidil, gingival hyperplasia due to cyclosporine and steroid acne from prednisolone. These skin disorders were significantly present in 14(10.1%) of the study population, while controls had no medication disorders (X2 =12.7; P = 0.0001). The distribution of skin disorders in this fourteen patients, showed that 7 (50%) had hypertrichosis, 5 (36%) had steroid acne and 2 (14%) had gingival hyperplasia. Five patients on dialysis had medication related disorders, with four (5.3%) having hypertrichosis and one (1.3%) having steroid acne. Four (40%) of the ten transplant patients had medication related disorders with two having gingival hyperplasia and the others steroid acne. Five patients ((9%) who were conservatively managed had medication related disorders with three having hypertrichosis and two with steroid acne. Comparison of the three groups showed significant differences with X°= 10.85; P value = 0.04.

Conclusion: Medication related skin disorders are more common in patients with ESRD. The leading disorders are hypertrichosis, steroid acne and gingival hyperplasia. It is important for physicians to be aware of these complications so that alternative drugs that would improve the quality of life of patients with ESRD can be used.

Downloads

Published

2015-12-13

How to Cite

Otike-Odibi, B., & Okunoye, O. C. (2015). Medication Related Cutaneous Disorders in End Stage Renal Disease Patients in Lagos. The Nigerian Health Journal, 13(4), 146. Retrieved from https://tnhjph.com/index.php/tnhj/article/view/109

Most read articles by the same author(s)

Similar Articles

1 2 3 4 5 > >> 

You may also start an advanced similarity search for this article.