Medication Related Cutaneous Disorders in End Stage Renal Disease Patients in Lagos
DOI:
https://doi.org/10.60787/tnhj.v13i4.109Keywords:
Cutaneous disorders, Medication use, ESRD/CKDAbstract
Background: In End Stage Renal Disease (ESRD) patients, a wide range of cutaneous manifestations are present which may be due to the medications prescribed. Most patients' with ESRD are on numerous medications for their primary ailment, with transplant patients needing long term steroids and cytotoxics for allograft survival. The purpose of the study is to identify the medication related cutaneous disorders in End Stage Renal Disease patients and the causative drugs.
Methods: A simple random sampling technique was used to select 138 ESRD patients (GFR<15mls / min) from the Lagos University Teaching Hospital, Life Support and St Nicholas Hospital, Lagos, Nigeria as well as Renal transplant patients. Also 138 non-renal, non-hypertensive, non- diabetic patients from the medical wards of L. U.T.H, with Chronic Kidney disease stage 0, GFR > 90mls / min were used as controls. They were all examined for medication related disorders and list of drugs used collated.
Results: The ESRD patients consisted of seventy six (55%) on dialysis, fifty- two (38%) on conservative management and ten (7%) post-transplant.Medication related disorders included hypertrichosis due to cyclosporine and minoxidil, gingival hyperplasia due to cyclosporine and steroid acne from prednisolone. These skin disorders were significantly present in 14(10.1%) of the study population, while controls had no medication disorders (X2 =12.7; P = 0.0001). The distribution of skin disorders in this fourteen patients, showed that 7 (50%) had hypertrichosis, 5 (36%) had steroid acne and 2 (14%) had gingival hyperplasia. Five patients on dialysis had medication related disorders, with four (5.3%) having hypertrichosis and one (1.3%) having steroid acne. Four (40%) of the ten transplant patients had medication related disorders with two having gingival hyperplasia and the others steroid acne. Five patients ((9%) who were conservatively managed had medication related disorders with three having hypertrichosis and two with steroid acne. Comparison of the three groups showed significant differences with X°= 10.85; P value = 0.04.
Conclusion: Medication related skin disorders are more common in patients with ESRD. The leading disorders are hypertrichosis, steroid acne and gingival hyperplasia. It is important for physicians to be aware of these complications so that alternative drugs that would improve the quality of life of patients with ESRD can be used.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2015 The Nigerian Health Journal
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The Journal is owned, published and copyrighted by the Nigerian Medical Association, River state Branch. The copyright of papers published are vested in the journal and the publisher. In line with our open access policy and the Creative Commons Attribution License policy authors are allowed to share their work with an acknowledgement of the work's authorship and initial publication in this journal.
This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author.
The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations. While the advice and information in this journal are believed to be true and accurate on the date of its going to press, neither the authors, the editors, nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein.
TNHJ also supports open access archiving of articles published in the journal after three months of publication. Authors are permitted and encouraged to post their work online (e.g, in institutional repositories or on their website) within the stated period, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). All requests for permission for open access archiving outside this period should be sent to the editor via email to editor@tnhjph.com.
