Plasmodium falciparum Kelch 13-propeller gene mutation update in Nigeria – a systematic review
DOI:
https://doi.org/10.60787/tnhj.v23i2.670Keywords:
K13-propeller gene polymorphism, Artemisinin resistance, Malaria, Plasmodium falciparum, Nigeria.Abstract
Background: Mutations in Plasmodium falciparum Kelch 13 propeller gene has been associated with artemisinin resistance. This review is a synthesis of evidence from research on Plasmodium falciparum Kelch 13 (Pfk13) propeller gene mutations conducted in Nigeria from 2011 to 2023 to determine the extent of spread of Pfk13 mutations in different states of Nigeria.
Methods: An electronic search of studies from 2011 to date was done in Medline via PubMed, database and Google Scholar using Mesh terms and Boolean operators. PRISMA guidelines were used to guide the screening of articles for inclusion. Data extraction form was developed in Excel 2016 and used for data extraction.
Results: A total of 84 articles were retrieved but only 12 were eligible for inclusion. Pfk13 gene mutations studies have been conducted in 11 out of 36 (30.6%) states of Nigeria. The total number of independent Pfk13 mutations identified across the different states was 44, 32 (72.7%) mutations were novels. None of the reported mutations in this review was among the validated k13 mutations associated with increased artemisinin resistance.
Conclusion: Number of Pfk13 gene mutations studies in Nigeria was scanty. States in the North-east, North-west, and South-south geopolitical regions of Nigeria have the poorest coverage. Pfk13 gene mutations including novel ones were identified, however, they were all non-validated k13 mutations. There is need to carry out further studies (in vitro and in vivo) to ascertain the role of these novel mutations in emergence and spread of ART resistance in Nigeria.
Downloads
Downloads
Published
Versions
- 2023-07-20 (2)
- 2023-07-10 (1)
How to Cite
Issue
Section
License
Copyright (c) 2023 Journal and Publisher
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The Journal is owned, published and copyrighted by the Nigerian Medical Association, River state Branch. The copyright of papers published are vested in the journal and the publisher. In line with our open access policy and the Creative Commons Attribution License policy authors are allowed to share their work with an acknowledgement of the work's authorship and initial publication in this journal.
This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author.
The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations. While the advice and information in this journal are believed to be true and accurate on the date of its going to press, neither the authors, the editors, nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein.
TNHJ also supports open access archiving of articles published in the journal after three months of publication. Authors are permitted and encouraged to post their work online (e.g, in institutional repositories or on their website) within the stated period, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). All requests for permission for open access archiving outside this period should be sent to the editor via email to editor@tnhjph.com.
