An HIV-1 Infected Patient with Neurofibromatosis Type 1: A Case Report

Authors

  • Samson Ejiji Isa Department of Medicine, Jos University Teaching Hospital, Jos
  • Akindele Silas Department of Pathology, Jos University Teaching Hospital, Jos
  • Comfort Daniyam Department of Medicine, Jos University Teaching Hospital, Jos
  • Mike Iroezindu Department of Medicine, Jos University Teaching Hospital, Jos
  • Ajuma Agaba Department of Family Medicine Jos University Teaching Hospital, Jos

DOI:

https://doi.org/10.60787/tnhj.v12i2.91

Keywords:

Neurofibromatosis type 1, HIV Infection, Cutaneous lesions, HAART

Abstract

Background: Although HIV-1 infection predisposes an individual to well defined neoplasia, neurofibromas have not been reported as some of the typical ones. The association between HIV-1 infection and neurofibromatosis type 1, a genetic disorder, should be of interest because HIV infection could alter the natural biology of its cutaneous manifestations. However, reports on simultaneous occurrence of these conditions in an individual are rare.

Method: The case records of a 30 year old HIV 1 positive female receiving care at the Jos University teaching hospital centre and a review of the relevant literature was utilised.

Result: We present a 30 year old HIV positive woman with florid cutaneous lesions of familial neurofibromatosis type 1 who had adequate response to antiretroviral therapy

Conclusion: HIV infection and treatment did not seem to affect the clinico- pathological features of the neurofibromatosis lesions

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References

Huson SM, Compston DAS, Clark P, et al. A genetic study of von Recklinghausen neurofibromatosis in south east Wales: prevalence, fitness, mutation rate, and effect of parental transmission on severity. J Med Genet 1989; 26: 704–11

Atadzhanov M. Hereditary neurological diseases at University Teaching Hospital, Lusaka. neurological diseases. Downloaded on the 6 December, 2011.

Nyandaiti YW, Tahir C, Nggada HA, Ndahi AA. Clinico-pathologic presentation and management ofneurofibromatosis type 1 disease among north-eastern Nigerians: A six year review. Nmj. 2009; 50: 80-83.

Xu GF, O'Connell P, Viskochil D, et al. The neuro?bromatosis type 1 gene encodes a protein related to GAP. Cell 1990; 62: 599–608.

SA Rasmussen, JM Friedman. NF1 Gene and Neurofibromatosis 1. AjE. 2000; 151: 33-39.

Newcomb-Fernandez J. Cancer in the HIV-infected population. Res Initiat Treat Action. 2003; 9: 5-13.

Demopoulos BP, Vamvakas E, Ehrlich JE and Demopoulos R. Non-Acquired Immunodeficiency Syndrome-defining malignancies in patients infected with Human Immunodeficiency Virus. Arch Path Lab Med. 2003; 127: 589-592.

Spano JP, Atlan D, Breau JL, Farge D. AIDS and non-AIDS-related malignancies: a new vexing challenge in HIV-positive patients. Part I: Kaposi's sarcoma, and Hodgkin's lymphoma. Eur J Int Med 13: 170-179, 2002.

Mbulaiteye SM, Biggar RJ, Goedert JJ, Engels EA. Immune deficiency and risk for malignancy among persons with AIDS. J Acquir Immune Defic Syndr 32: 527-533, 2003.

National Institutes of Health Consensus Development Conference Statement: neuro?bromatosis. Arch Neurol 1988; 45: 575–78.

Odebode TO, Afolayan AO, Adigun AI, Daramola OO. Clinicopathological study of Neurofibromatosis type 1: an experience in Nigeria. Int J Derm. 2005; 44: 116-120.

Sivayathorn A, Sriha B, Leesanguankul W. Prevalence of skin diseases in patients with HIV in Bankok, Thailand. Ann Acad Med Singapore. 1995; 24: 528-533.

Leppard B. An Atlas of African Dermatology. Oxon. Radcliffe Medical Press Ltd. 2002: 268-270.

Waugh M. Skin diseases- clinical indicator of immune status in HIV infection. Int J Dermatol 2007;44:705-706

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Published

2015-12-09

How to Cite

Isa, S. E., Silas, A., Daniyam, C., Iroezindu, M., & Agaba, A. (2015). An HIV-1 Infected Patient with Neurofibromatosis Type 1: A Case Report. The Nigerian Health Journal, 12(2), 52. https://doi.org/10.60787/tnhj.v12i2.91
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