Prevalence of Chlamydia Trachomatis Infection among Female Undergraduates of the University of Port Harcourt Using Strand Displacement and Amplification [SDA] Technique
DOI:
https://doi.org/10.60787/tnhj.v12i2.87Keywords:
Prevalence, Chlamydia trachomatis, Strand Displacement and Amplification [SDA] TechniqueAbstract
Background: Chlamydia trachomatis infection, being largely asymptomatic, is difficult to diagnose using the common diagnostic methods which have varying degrees of sensitivity and specificity. There is a paucity of data on the prevalence of Chlamydia trachomatis infection in Nigeria. The aim of this research is to determine the prevalence of and predictive risk factors for Chlamydia trachomatis infection among female undergraduate students of the University of Port Harcourt.
Methods: Four hundred undergraduate, non-pregnant, asymptomatic female students below the age of 30 years were randomly selected and given questionnaires with self-administrable vaginal swab sticks. The participants completed the questionnaires and provided vaginal swab samples which were analyzed using Strand Displacement and Amplification Technique.
Results: Of the 400 sexually active participants, 44 tested positive [prevalence rate of 11%] for Chlamydia trachomatis. Some of the associated risks factors identified were, having multiple sexual partners especially in the last 90 days, irregular contraceptive usage and past history of sexually transmitted infections.
Conclusion: There is an urgent need for a national policy on routine screening for Chlamydia trachomatis as treatment is cheap and effective, while the morbidity resulting from delayed diagnosis is more difficult to manage and associated with severe sequelae
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References
World Health Organization. Global prevalence and incidence of selected sexually transmitted infections. Overview and estimates. Geneva: WHO, 2001.
Awwad Z M, Al-Amarat AA , Shehabi AAA. Prevalence of genital Chlamydial infection in Symptomatic and Asymptomatic Jordanian patients. Int J. Infect Dis. 2003; 7: 206–209.
Mpiga P , Ravaoarimoro M. Chlamydia trachomatis persistence: An update. Microbiological Research. 2006; 161: 9–16.
World Health Organization Task Force on Prevention and Management of Infertility. Tubal infertility: Serological relationship to Past Chlamydia and Gonococcal infection. Sex Transm Dis. 1995: 22: 71–77.
Scieh, ISD, National Public Health Service for Wales. Renewing the focus, HIV and other sexually transmitted infections in the United Kingdom in 2002. London: Health Protection Agency, 2002
Howell MS, Quinn TC, Braithwaite W, et al. Screening women for Chlamydia trachomatis in family planning clinics. The cost effectiveness of DNA amplification assays. Sex Transmit Dis .1998: 25: 108-117.
Adams E. J, Charlett A, Edmunds WJ, et al. Chlamydia trachomatis in the United Kingdom: A systematic review and analysis of prevalence studies. Sex Transm Infect 2004: 80: 354–362.
Committee for Quality Assurance. State of health care quality report, 2003. Washington DC: National Committee for Quality Assurance, 2003: 1–60.
Meyers DS, Halvorson H, Luckhaupt S. Screening for Chlamydial infection: An evidence update for the United States Preventive Services Task Force. Ann Intern Med. 2007: 147: 100-200
Center for Disease Control and Prevention. Recommendations for the prevention and management of Chlamydia trachomatis infections. Morbid. Mortal. Weekly Rep. 1993; 42 [No, RR-12]:1-39.
Stamm WE, Koutsky LA, Benedetti JK, Jourdeu JL, Brunham RC and Holmes KK. Chlamydia trachomatis urethral infections in men. Prevalence, risk factors and clinical manifestations. Am. Intern. Med. 1984; 100: 47-51.
Cheng HM, Macaluso SH Vermund HH , Hook EW. Relative accuracy of nucleic acid amplification test and culture in detecting Chlamydia in asymptomatic men. Journal of Clinical Microbiology. Nov, 2001; 39. II: 3927–3937.
Obunge OK, John CT. The role of genital Chlamydial infection in Acute Pelvic Inflammatory Disease. Afr. J. Cln. Exper. Microbio. 2007; 8910: 23–27
Parratt JR, Hay DP. Sexually transmitted infections. Current Obstetrics and Gynecology, 2003; 13: 224–230.
Debattista J, Timms P, Allan J, Allan JA. Immuno Pathogenesis of Chlamydia trachomatis infections in women. Fertility and Sterility.2003; 79, 6: 1273-1287.
Schachter JM, Grossman M, Sweet RL, Holt J, Jordan C , Bishop E. Prospective study of perinatal transmission of Chlamydia trachomatis. JAMA. 1986; 255: 3374- 3377.
Laga M, Mamoka M , Kivuvu B, et al. Non- ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: Results from a cohort study. AIDS 1993; 7: 95-102.
Pearlman MD, McNeeley SG. A review of the Microbiology, Immunology and Clinical implications of Chlamydia trachomatis infections. Obstet. Gynecol. Surv. 1992; 47: 448-461.
Hills SD, Nakashima A, Marchbanks PA, Addiss DG , Davis JP. Risks factors for recurrent Chlamydia trachomatis in women. Am. J. Obstet. Gynecol.1994; 170: 801-806.
Black CM. Current methods of laboratory diagnosis of Chlamydia trachomatis infections. Clin. Microbiol. Rev. 1997; 10: 160-184.
Schepetiuk S, Kok T , Martin L, et al. Detection ofChlamydia trachomatis in urine samples by nucleic acid tests. Comparison with culture and enzyme immunoassay of genital swab specimens. J. Clin. Microbiol 1997; 35: 3355–3357.
Cook RL, Hutchison SL, Ostergard L, Braithwaite RS and Ness RB. Systematic review, non invasive testing for Chlamydia trachomatis and Nesseria gonorrhea. Ann Intern Med 2005; 142: 914–925.
Paavonen J. Is screening for Chlamydia trachomatis cost effective? Genitour Med. 1997; 73: 103–104.
Howell RM, Thomas CQ, Charlotte AG. Screening for Chlamydia trachomatis in Asymptomatic Women Attending Family Planning Clinics: A Cost-Effectiveness Analysis of Three Strategies. Annals ofInternal Medicine 1998; 128: 277–284.
Nyari T, Wood MW , Kovacs L. Should all sexually active young women in Hungary be screened for Chlamydia trachomatis? European Journal ofObstetrics and Gynecology and Reproductive Biology 2003; 106: 55–59.
Jungkind DS, Direnzo KG, Beavis R, Silverman NS. Evaluation of automated COBRAS AMPLICOR PCR system for detection of several infectious agents and its impact on laboratory management. J. Clin. Microbiol. 1996; 34 : 2778–2783.The Nigerian Health Journal, Vol. 12, No 2, April — June, 2012Wariso KT, et al — Prevalence of Chlamydia trachomatis infection
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