Causes of initiation of HIV postexposure prophylaxis in a tertiary health care institution in Southeastern Nigeria

Authors

  • Emmanuel Chukwuma Ufornwa Medical Research Department, Federal Medical Centre, Owerri, Imo State, Nigeria.
  • Henshaw Uchechi Okoroiwu Haematology Unit, Department of Medical Laboratory Science, University of Calabar, Nigeria.

DOI:

https://doi.org/10.60787/tnhj.v21i3.527

Keywords:

HIV, postexposure prophylaxis, PEP, occupational exposure, on-occupational exposure, HIV exposure.

Abstract

Background: Postexposure prophylaxis is useful in prevention of seroconversion in event of occupational and non-occupational exposures to infective body fluids. This study is aimed at probing the factors that predicted initiation of PEP against HIV in our study centre.

Methods: The study was a retrospective evaluation of the data of subjects that presented for PEP in the Heart-to-Heart HIV Clinic, Federal Medical Centre, Owerri from January 2008 to December 2013. Results were represented in frequencies and proportion. Chi square was used to assess association.

Results: The age range 15 – 24 (47.6%) and 25 – 34 years (31.5%) dominated the number of those presenting for PEP with female gender preponderance. Rape constituted the major reason for overall presentation for PEP as well as non-occupational reason for exposure while needle prick injury was the major reason for occupational exposure (14.3%). Rape, needle prick, unprotected sex, broken condom, blood contact represented 69.9%, 14.3%, 8.2%, 4.1%, 2.6% and 1.1%, respectively of the subjects presenting for PEP. Students represented the bulk of the subjects presenting for PEP and also represented majority of the rape cases (80.7%).

Conclusion: Rape and needle prick injury represented majority of the cases under study. This finding exposes the vulnerability of the females as well as healthcare providers. Adequate policy against rape and training on proper handling and disposal of sharp equipment becomes necessary to reduce these occurrences.    

Downloads

Download data is not yet available.

Author Biographies

Emmanuel Chukwuma Ufornwa, Medical Research Department, Federal Medical Centre, Owerri, Imo State, Nigeria.

BSc, MSc.

Henshaw Uchechi Okoroiwu, Haematology Unit, Department of Medical Laboratory Science, University of Calabar, Nigeria.

Medical Laboratory Science. B.MLS, MSc., PhD

References

Adebimpe WO. Knowledge and practice of healthcare workers towards post-exposure prophylaxis in the era of low and stable HIV prevalence in Southwest Nigeria. Bulletin of Faculty of Pharmacy, Cairo Egypt. 2018;56: 104-108.

World Health Organization (WHO). Global Health Observation (GHO) data: HIV/AIDS. Available at: www.who.gho/hiv/en. Accessed November 22, 2018.

Okoroiwu HU, Okafor IM, Asemota EA, Okpokam DC. Seroprevalence of transfusion-transmissible infections (HBV, HCV, Syphilis and HIV) among prospective blood donors in a tertiary health care facility in Calabar, Nigeria: an eleven years evaluation. BMC Public Health. 2018;18: 645.

Joint United Nations Programme on HIV and AIDS (UNAIDS). The Gap Report: Children and pregnant women living with HIV. Geneva. 2014.

Joint United Nations Programme on HIV and AIDS. Country fact sheets; Nigeria. 2017. Available at: www.unaids.org/en/regionscountries/nigeria. Accessed November 22, 2018.

Joint United Nations Programme on HIV and AIDS. Country fact sheets; South Africa. 2017. Available at www.unaids.org/en/regionscountries/southafrica. Accessed November 22, 2018.

Awofala AA, Ogundele OE. HIV Epidemiology in Nigeria. Saudi Journal of Biological Research. 2018;25(4): 697-703.

Singh RK, Kumar M, Rawat CMS, Rawat V. Awareness and practice of post-exposure prophylaxis (PEP) of HIV among healthcare workers in tertiary healthcare hospital of Haldwani, Nainital, Uttarakhand, India. International Journal f Medical Science and Public Health. 2015;4(7): 977-981.

World Health Organization (WHO)/ILO. Occupational post-exposure prophylaxis for HIV infection (HIV-PEP), in: Joint ILO/WHO Technical meeting for development of policy and guidelines. Geneva, 2005.

Tetteh RA, Nartey ET, Larfey M, Mantel-Teeuwisse AK, Leufkens HGM, Nortey PA, et al. Adverse events and adherence to HIV post-exposure prophylaxis: a cohort study at the Korle-Bu Teaching Hospital in Accra. BMC Public Health. 2015;15: 573.

National guidelines for HIV and AIDS treatment and care in adolescents and adults. Nigeria Federal Ministry of Health Abuja. 2007.

World Health Organization. HIV/AIDS: Post exposure prophylaxis to prevent HIV infection. Factsheet –1, December 2014. Available at: http://www.who.int/hiv/topics/prophylaxis/iunfo/en/ Accessed November 23, 2018.

World Health Organization. Post exposure prophylaxis for HIV. Supplementary section to 2013 WHO consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection, Chapter 5 – Clinical guidelines across the continuum of care: HIV diagnosis and ARV drugs for HIV prevention. WHO, Geneva. 2013.

Onyedum CC, Chukwuka C, Iyoke CA, Omotola OF. HIV post exposure prophylaxis (PEP) in a Nigerian Tertiary Health Institution. Journal of the International Association of Physicians in AIDS Care. 2011;10(3): 171-175.

Marfatia YS, Jose SK, Basci RR, Shah RJ. Pre- and Post-sexual exposure prophylaxis of HIV: an update. Indian J Sex Transm Dis AIDS. 2017;38(1): 1-9.

Garcia_Lerma JG, Cong ME, Mitchel J, Youngpairoj AS, Zheng Q, Masciotra S, et al. Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection. Sci Trans/ Med. 2010;2: 14ra4.

Tsai C, Emau P, Follis KE, Beck TW, Benveniste RE, Bischofberger N, et al. Effectiveness of Postinoculation (R)-9-(2-phosphonylmethoxypropyl) adenine treatment for prevention of persistent Simian Immunodeficiency Virus SIVmne Infection depends critically on timing of initiation and duration of treatment. J Virol. 1998;72(5): 4265-4273.

Otten RA, Smith DK, Adams DR, Pullium JK, Jackson E, Kim CN, et al. Efficacy of Post exposure prophylaxis after intravaginal exposure of pig-tailed macaques to a human-Derived Retrovirus (Human Immunodeficiency Virus type 2). J Virol. 2000;74(20): 97719776.

Sultan B, Benn P, Waters L. Current perspectives in HIV post-exposure prophylaxis. HIV-AIDS-Research Pallitative care. 2014;6: 147-58.

Karen B, Helen H, Warren P, Zinhle N. Post exposure prophylaxis (PEP) in South Africa, analysis of calls to the National AIDS. Help Line. 2004.

Department of Health. HIV Post exposure prophylaxis; Guidance from the UK Chief Medical Officer Expert Advisory Group on AIDS. 2008.

Gerberding JL. Occupational exposure to HIV in healthcare settings. N Engl J Med. 2003;348(11): 826-33.

Young TN, Arens FJ, Kennedy GE, Laurie JW, Rutherford G. Antiretroviral post-exposure prophylaxis for occupational HIV exposure. Cochrane Database Syst Rev. 2007;(1):CD002835.

Eluwa GI, Badru T, Agu AK, Akpoigbe KJ, Chabikuli O, Hamelmann C. Adverse drug reactions to antiretroviral therapy (ARVs); incidence, types and risk factors in Nigeria. BMC Clin Pharmacol. 2012;12: 7.

Dean GL, Edward SG, Ives NJ, Matthews G, Fon EF, Navaratne L, et al. Treatment of tuberculosis in HIV-infected parsons in the era of highly active antiretroviral therapy. Aids. 2002;16(1): 75-83.

National bureau of statistics. Annual Abstract of Statistics 2011. National Bureau for Statistics, Federal Republic of Nigeria. 2011.

National Agency for the Control of Aids (NACA). Nigeria Prevalence Rate. Available at: http://naca.gov.ng/nigeria-prevalence-rate/. Accessed November 23, 2018.

Olowookere SA, Fatiregun AA. Human Immunodeficiency Virus Post exposure Prophylaxis at Ibadan, Nigeria. Journal of the International Association of Physicians in AIDS Care. 2010;9(3): 187-190.

Erhabor O, Ejele OA, Nwauche CA. Epidemiology and management of occupational exposure to blood borne viral infections in a resource poor setting: the case for availability of post exposure prophylaxis. Nigerian Journal of Clinical Practice. 2007;10(2): 100-104.

Merchant RC, Mayer KH, Becker BM, Delong AK, Hogan JW. Predictors of the initiation of HIV post exposure prophylaxis in Rhode Island Emergency Department. AIDS Patient Care AIDS. 2008;22(1): 41-52.

Silka A, Nyandiko W, Mwanyi A, Waxman M, Sidle JE, Kimaiyo S, et al. The structure and outcomes of a HIV post exposure prophylaxis programme in a high HIV prevalence setup in Western Kenya. Journal of Acquired Immune Deficiency Syndromes. 2009;51(1): 47-53.

Akinlusi FM, Rabiu KA, Olawepo TA, Adewunmi AA, Ottun TA, Akinola OI. Sexual assaults in Lagos, Nigeria: a five year retrospective review. BMC Women Health. 2014;14: 115.

Haile RT, Kebeta ND, Kassie GM. Prevalence of sexual abuse of male high school students in Addis Ababa, Ethiopia. BMC Int Health Hum Rights. 2013;13: 24.

Badejoko OO, Anyabolu HC, Badejoko BO, Ijarotimi AO, Kuti O, Adejuyigbe EA. Sexual assaults in Ile-Ife, Nigeria. Niger Med J. 2014;55: 254-259.

Akinade E, Adewuyi T, Sulaiman A. Socio-Legal factors that influence the perpetuation of rape in Nigeria. Procedia-Social and Behavioural Sciences. 2010;5: 1760-4.

Kullima AA, Kawuwa MB, Audu BM, Mairiga AG, Bukar M. Sexual assault against female Nigerian students. Afr J Reprod Health. 2010;14(3): 189-193.

Adeleke NA, Olowookere AS, Hassan MB, Kololafe JO, Asekun-Olarinmoye EO. Sexual assault against women at Osogbo Southwestern Nigeria. Niger J Clin Pract. 2012;15(2): 190-193.

Ezechi OC, Adesolamusa Z, David AN, Wapmuk AE, Gbajabiamila TA, Idigbe IE. Trends and patterns of sexual assaults in Lagos, southwestern Nigeria. Pan Afr Med J. 2016;24: 261.

Hamlyn E, Easterbrook P. Occupational exposure to HIV and the use of post exposure prophylaxis. Occup Med. 2007;57(5): 329-336.

Owolabi RS, Ajayi S, Ogundiran A, Onafowokan T. knowledge and practice of postexposure prophylaxis (PEP) against HIV infection among health care providers in a tertiary hospital in Nigeria. Journal of the International Association of Physicians in AIDS Care. 2011;000(00):1-5.

National Bureau of Statistics. National manpower stock and employment generation survey; household and micro enterprise (informed sector). National Bureau of Statistics. 2010.

Presidential Emergency Plan for AIDS Relief (PEPFAR). PEPFAR strategy country factsheet: Nigeria. Available at: www.pepfar.gov. Accessed November 19, 2018.

World Health Organization: Global Health Workforce alliance. FHI 360. Available at: www.who.int/workforcealliance/members_partners/member_list/fhi/en/. Accessed on November 19, 2018.

National Agency for the control of AIDS (NACA). Factsheet: HIV prevention programme. Available at: https://naca.gov.ng/. Accessed on November 19, 2018.

Downloads

Published

2022-01-30

How to Cite

Ufornwa, E. C., & Okoroiwu, H. U. (2022). Causes of initiation of HIV postexposure prophylaxis in a tertiary health care institution in Southeastern Nigeria. The Nigerian Health Journal, 21(3), 149–167. https://doi.org/10.60787/tnhj.v21i3.527
Abtract Views | PDF Download | EPUB Download: 279 / 24

Similar Articles

1 2 3 4 5 6 7 > >> 

You may also start an advanced similarity search for this article.