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Cord Blood Lipid Profile of Term and Preterm Newborns in a Tertiary Hospital in South East Nigeria: Relationship with Gestational Age and Birth Weight

Cord Blood Lipid Profile of Term and Preterm Newborns: Relationship with Gestational Age and Birth Weight

Authors

OV Obaji Senior Registrar, Department of Paediatrics, Federal Medical Centre, Umuahia, Abia State, Nigeria https://orcid.org/0000-0001-6425-3531
NK Chukwudi Consultant, Department of Paediatrics, Federal Medical Centre, Umuahia, Abia State, Nigeria https://orcid.org/0000-0002-8698-5167
DK Adiele Senior Lecturer and Consultant Paediatric Cardiologist, College of Medicine, Department of Paediatrics, University of Nigeria/University of Nigeria Teaching Hospital (UNTH), Ituku- Ozalla, Enugu State, Nigeria https://orcid.org/0000-0002-5325-2004
UC Adizua Consultant Chemical Pathologist, Federal Medical Centre, Umuahia, Abia State, Nigeria. https://orcid.org/0000-0001-6962-6421
JU Onu 5Consultant Psychiatrist, Department of Mental Health, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria https://orcid.org/0000-0002-4567-7096

DOI:

https://doi.org/10.60787/tnhj.v23i1.638

Keywords:

Cord blood lipid profile, Gestational age, Birth weight, Nigeria

Abstract

Abstract

Background: Early-onset atherosclerosis is a marker of future cardiovascular diseases. However, indicators of early dyslipidemia for primary prevention are generally lacking in sub-Saharan Africa. This study aimed at describing the cord blood lipid profile in Nigeria and its relationship with gestational age and birth weight.

Methods: Cross-sectional study of 167 consecutively recruited newborns in a tertiary hospital whose cord blood lipid profile parameters were assessed using an autoanalyzer (BiOLis 24i). Lipid variables were presented with descriptive statistics whereas their relationship with gestational age and birth weight was highlighted using correlation analysis.

Results: The median values (in mg/dL) of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL – C), low-density lipoprotein cholesterol (LDL – C) and very low-density lipoprotein cholesterol (VLDL – C) were 60.0, 30.5, 29.0, 25.8 and 6.1 respectively, all within the normal international ranges. Triglycerides and VLDL-C had a moderate positive correlation with gestational age (r_s= 0.4; p < 0.001) and were significantly higher in small-for-gestational-age newborns. Total cholesterol, HDL – C, and LDL-C had a weak negative correlation with gestational age and birth weight (spearman r_s ˂ - 0.3). Birth weight, gestational age, and paternal age were the common predictors of lipid profile variability.

Conclusion: The finding of a significant relationship between lipid variables with gestational age and birth weight underscores the need to clinically interpret these given the relationship. The relationship with paternal age is another interesting finding which needs to be replicated and the mechanism(s) elucidated.

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Published

2023-03-11

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2023-03-16 (2)
2023-03-11 (1)

How to Cite

Obaji, O., Chukwudi, N., Adiele, D., Adizua, U., & Onu, J. (2023). Cord Blood Lipid Profile of Term and Preterm Newborns in a Tertiary Hospital in South East Nigeria: Relationship with Gestational Age and Birth Weight : Cord Blood Lipid Profile of Term and Preterm Newborns: Relationship with Gestational Age and Birth Weight . The Nigerian Health Journal, 23(1), 478–488. https://doi.org/10.60787/tnhj.v23i1.638

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Issue

Vol. 23 No. 1 (2023)

Section

Original Articles

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