Carbamazepine Induced Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome
Carbamazepine induced DRESS
Keywords:DRESS, Carbamazepine, eosinophilia, drug reaction
Background: Drug reaction with eosinophilia and systemic symptoms syndrome is a rare adverse, life threatening drug reaction caused by several drugs including Carbamazepine. The objective of this report is to create awareness of this life threatening reaction to a commonly prescribed drug for seizure disorders.
Methods: This is a case report of drug eosinophilia syndrome in a 33-year old female following clinical and laboratory evaluation at the skin clinic for generalized erythematous rashes following the use of Carbamazepine.
Results: She was found to have generalized, scaly, erythematous papules, patches and plagues. Laboratory results included blood eosinophilia, elevated liver enzymes and histopathology report of spongiotic dermatitis with eosinophilic infiltrates.
Conclusion: Drug reaction with eosinophilia and systemic symptoms syndrome can be caused by Carbamazepine. A diagnosis of this rare life threatening drug reaction should be suspected in patients presenting with generalized erythematous rashes following the use of Carbamazepine.
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