Demographic And Clinical Profile Of Patients Diagnosed With Breast Cancer In Port Harcourt: Implications For Targeted Screening

Authors

  • Solomon N. Elenwo Department of Surgery, University of Port Harcourt Teaching Hospital, Port Harcourt
  • Rex Friday Ogoronte A. Ijah Department of Surgery, University of Port Harcourt Teaching Hospital, Port Harcourt
  • Alexander A. Dimoko Department of Surgery, University of Port Harcourt Teaching Hospital, Port Harcourt

DOI:

https://doi.org/10.60787/tnhj.v21i4.515

Keywords:

Demographic profile, Clinical profile, Breast cancer, Implications for Targeted Screening, Port Harcourt.

Abstract

Aim: This study aims at determining the demographic and clinical profile of patients diagnosed with breast cancer from July 2016 to June 2019 in Port Harcourt and their implications for targeted screening.

Background: The role of risk factors in breast cancer mortality has been reported. Statistics on breast cancer differ from region to region. Our unique regional characteristics, therefore, could be harnessed for future care.

Materials and Methods: This descriptive retrospective study was carried out at the breast clinic and general surgery wards of a tertiary healthcare facility using the medical records of all patients with histologically confirmed breast cancer seen between July 2016 and June 2019. Data was analyzed using the Statistical Package for the Social Sciences (SPSS) version 20.0.

Results: The median age at diagnosis of breast cancer was 41.0years with a range of 20 – 75years. The median age at menarche was 14.0years. Most of the patients, 47 (77.1%) presented with duration of symptoms of ≤12months. The most common stage at presentation was stage III cancer.

Conclusion: The relatively younger age at presentation/diagnosis of breast cancer in our subregion could be a strong and viable reason for advocacy for early commencement of age-targeted breast cancer screening from 25years.

Downloads

Download data is not yet available.

Author Biographies

Solomon N. Elenwo, Department of Surgery, University of Port Harcourt Teaching Hospital, Port Harcourt

Surgery Department, General Surgeon & Senior Lecturer

Rex Friday Ogoronte A. Ijah, Department of Surgery, University of Port Harcourt Teaching Hospital, Port Harcourt

Department of Surgery, General Surgeon

Alexander A. Dimoko, Department of Surgery, University of Port Harcourt Teaching Hospital, Port Harcourt

Department of Surgery, General Surgeon

References

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2018 Nov;68(6):394-424.

Amin SM, Ewunonu HA, Oguntebi E, Liman IM. Breast cancer mortality in a resource-poor country: A 10-year experience in a tertiary institution. Sahel Medical Journal. 2017 Jul 1;20(3):93.

Jedy-Agba E, Curado MP, Ogunbiyi O, Oga E, Fabowale T, Igbinoba F, Osubor G, Otu T, Kumai H, Koechlin A, Osinubi P. Cancer incidence in Nigeria: a report from population-based cancer registries. Cancer epidemiology. 2012 Oct 1;36(5):e271-8.

Tatalovich Z, Zhu L, Rolin A, Lewis DR, Harlan LC, Winn DM. Geographic disparities in late stage breast cancer incidence: results from eight states in the United States. International journal of health geographics. 2015 Dec 1;14(1):31.

Garland FC, Garland CF, Gorham ED, Young JF. Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation. Preventive medicine. 1990 Nov 1;19(6):614-22.

Toikkanen SP, Kujari HP, Joensuu H. Factors predicting late mortality from breast cancer. European Journal of Cancer and Clinical Oncology. 1991 May 1;27(5):586-91.

Gaskill SP, McGuire WL, Osborne CK, Stern MP. Breast cancer mortality and diet in the United States. Cancer research. 1979 Sep 1;39(9):3628-37.

Daling JR, Malone KE, Doody DR, Anderson BO, Porter PL. The relation of reproductive factors to mortality from breast cancer. Cancer Epidemiology and Prevention Biomarkers. 2002 Mar 1;11(3):235-41.

Connor SR, Pyenson B, Fitch K, Spence C, Iwasaki K. Comparing hospice and nonhospice patient survival among patients who die within a three-year window. Journal of pain and symptom management. 2007 Mar 1;33(3):238-46.

Sighoko D, Ogundiran T, Ademola A, Adebamowo C, Chen L, Odedina S, Anetor I, Ndom P, Gakwaya A, Ojengbede O, Huo D. Breast cancer risk after full‐term pregnancies among A frican women from N igeria, C ameroon, and U ganda. Cancer. 2015 Jul 1;121(13):2237-43.

Calle EE, Murphy TK, Rodriguez C, Thun MJ, Heath Jr CW. Occupation and breast cancer mortality in a prospective cohort of US women. American journal of epidemiology. 1998 Jul 15;148(2):191-7.

Loomis DP, Savitz DA, Ananth CV. Breast cancer mortality among female electrical workers in the United States. J Natl Cancer Inst 1994;86:921-5

Heck KE, Wagener DK, Schatzkin A, Devesa SS, Breen N. Socioeconomic status and breast cancer mortality, 1989 through 1993: an analysis of education data from death certificates. American Journal of Public Health. 1997 Jul;87(7):1218-22.

Lund E, Jacobsen BK. Education and breast cancer mortality: experience from a large Norwegian cohort study. Cancer Causes & Control. 1991 Jul 1:235-8.

Lim SE, Back M, Quek E, Iau P, Putti T, Wong JE. Clinical observations from a breast cancer registry in Asian women. World journal of surgery. 2007 Jul 1;31(7):1387-92.

Ihekwaba F. Breast cancer in Nigerian women. British Journal of Surgery. 1992;79(8):771-5.

Shinde SS, Forman MR, Kuerer HM, Yan K, Peintinger F, Hunt KK, et al. Higher parity and shorter breastfeeding duration: association with triple‐negative phenotype of breast cancer. Cancer. 2010;116(21):4933-43.

Huo D, Adebamowo C, Ogundiran T, Akang E, Campbell O, Adenipekun A, et al. Parity and breastfeeding are protective against breast cancer in Nigerian women. British journal of cancer. 2008;98(5):992-6.

Jamabo R, Eke N, John C. Pregnancy-associated breast cancer; a management dilemma in Nigeria. Sahel Medical Journal. 2004;7(2):69-72.

Anyanwu SN. Temporal trends in breast cancer presentation in the third world. Journal of Experimental & Clinical Cancer Research. 2008;27(1):17.

Adesunkanmi A, Lawal O, Adelusola K, Durosimi M. The severity, outcome and challenges of breast cancer in Nigeria. The Breast. 2006;15(3):399-409.

Agarwal G, Pradeep P, Aggarwal V, Yip C-H, Cheung PS. Spectrum of breast cancer in Asian women. World journal of surgery. 2007;31(5):1031-40.

Fan L, Strasser-Weippl K, Li J-J, St Louis J, Finkelstein DM, Yu K-D, et al. Breast cancer in China. The lancet oncology. 2014;15(7):e279-e89.

Rodríguez‐Cuevas S, Macías CG, Franceschi D, Labastida S. Breast carcinoma presents a decade earlier in Mexican women than in women in the United States or European countries. Cancer. 2001;91(4):863-8.

El Saghir NS, Khalil MK, Eid T, El Kinge AR, Charafeddine M, Geara F, et al. Trends in epidemiology and management of breast cancer in developing Arab countries: a literature and registry analysis. International journal of surgery. 2007;5(4):225-33.

Ghiasvand R, Bahmanyar S, Zendehdel K, Tahmasebi S, Talei A, Adami H-O, et al. Postmenopausal breast cancer in Iran; risk factors and their population attributable fractions. BMC cancer. 2012;12(1):414.

DeSantis CE, Ma J, Goding Sauer A, Newman LA, Jemal A. Breast cancer statistics, 2017, racial disparity in mortality by state. CA: a cancer journal for clinicians. 2017;67(6):439-48.

Sondik EJ. Breast cancer trends Incidence, mortality, and survival. Cancer. 1994;74(S3):995-9.

Smith-Bindman R, Chu PW, Miglioretti DL, Sickles EA, Blanks R, Ballard-Barbash R, et al. Comparison of screening mammography in the United States and the United Kingdom. Jama. 2003;290(16):2129-37.

Garza MA, Luan J, Blinka M, Farabee-Lewis RI, Neuhaus CE, Zabora JR, et al. A culturally targeted intervention to promote breast cancer screening among low-income women in East Baltimore, Maryland. Cancer Control. 2005;12(4_suppl):34-41.

Song H, Wang R, Wang S, Lin J. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proceedings of the National Academy of Sciences. 2005;102(13):4700-5.

Hall P, Easton D. Breast cancer screening: time to target women at risk. Nature Publishing Group; 2013.

Tosteson AN, Stout NK, Fryback DG, Acharyya S, Herman BA, Hannah LG, et al. Cost-effectiveness of digital mammography breast cancer screening. Annals of internal medicine. 2008;148(1):1-10.

Giamas G, Filipović A, Jacob J, Messier W, Zhang H, Yang D, et al. Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer. Nature medicine. 2011;17(6):715.

Ukwenya A, Yusufu L, Nmadu P, Garba E, Ahmed A. Delayed treatment of symptomatic breast cancer: the experience from Kaduna, Nigeria. South African Journal of Surgery. 2008;46(4).

Ibrahim N, Oludara M. Socio-demographic factors and reasons associated with delay in breast cancer presentation: a study in Nigerian women. The Breast. 2012;21(3):416-8.

Adebamowo C, Ogundiran T, Akang E. Epidemiology of triple negative breast cancer in Nigerian women. Journal of Clinical Oncology. 2006;24(18_suppl):10504-.

Huo D, Ikpatt F, Khramtsov A, Dangou J-M, Nanda R, Dignam J, et al. Population differences in breast cancer: survey in indigenous African women reveals over-representation of triple-negative breast cancer. Journal of Clinical Oncology. 2009;27(27):4515.

Gukas I, Jennings B, Mandong B, Igun G, Girling A, Manasseh A, et al. Clinicopathological features and molecular markers of breast cancer in Jos, Nigeria. West African journal of medicine. 2005;24(3):209-13.

Adisa C, Eleweke N, Alfred AA, Campbell M, Sharma R, Nseyo O, et al. Biology of breast cancer in Nigerian women: A pilot study. Annals of African medicine. 2012;11(3):169.

Ikpatt O, Kuopio T, Ndoma-Egba R, Collan Y. Breast cancer in Nigeria and Finland: epidemiological, clinical and histological comparison. Anticancer research. 2002;22(5):3005-12.

Ikpat O, Ndoma-Egba R, Collan Y. Influence of age and prognosis of breast cancer in Nigeria. East African medical journal. 2002;79(12):651-7.

Ikpatt O, Ndoma-Egba R. Oestrogen and progesterone receptors in Nigerian breast cancer: relationship to tumour histopathology and survival of patients. The Central African journal of medicine. 2003;49(11-12):122-6.

Downloads

Published

2022-01-30

How to Cite

Elenwo, S. N., Ijah, R. F. O. A., & Dimoko, A. A. (2022). Demographic And Clinical Profile Of Patients Diagnosed With Breast Cancer In Port Harcourt: Implications For Targeted Screening. The Nigerian Health Journal, 21(4), 174–186. https://doi.org/10.60787/tnhj.v21i4.515
Abtract Views | PDF Download | EPUB Download: 600 / 31

Similar Articles

<< < 18 19 20 21 22 23 24 25 26 27 > >> 

You may also start an advanced similarity search for this article.