Influence of Renal Impairment on Outcome of Patients with Multiple Myeloma: a Ten-Year Single Center Experience
DOI:
https://doi.org/10.60787/tnhj.v17i2.300Keywords:
renal impairment, multiple myeloma, NigeriaAbstract
Background: Renal impairment (RI) is an important complication occurring in 20 – 50% of newly diagnosed patients with multiple myeloma. It adversely affects overall survival and outcome in these patients. This study aims to assess RI in newly diagnosed multiple myeloma patients presenting at a tertiary hospital in the South-South region of Nigeria.
Methods: This was a ten-year retrospective study conducted on cases with confirmed multiple myeloma from August 2006 to July 2016. Renal impairment was determined using eGFR formula calculated by MDRD formula. Data analysis was done using statistical software package Microsoft Xcel® 2013.
Results: A total of 29 patients were diagnosed with MM within the period, with a male to female ratio of 1.9: 1. The median age at diagnosis was 60 years. Renal impairment occurred in 15 (51.7%) of cases. One (6.7%) patient presented with eGFR <15 signifying end stage renal disease requiring dialysis. Significantly more patients with lambda chain disease had RI compared to patients with kappa chain disease. Patients with RI were significantly more at risk of death than those with normal renal function [hazards ratio 12.1 at 95% CI; p = 0.03]. The group with RI had an estimated 5 year OS of 40.8% compared to those without RI who had an OS of 85.7%; (hazards ratio 2.46, at 95% CI).
Conclusion: Renal impairment remains a common presentation in patients newly diagnosed with multiple myeloma. The presence of RI at diagnosis is a poor prognostic feature affecting survival of myeloma cases.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2018 The Nigerian Health Journal
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The Journal is owned, published and copyrighted by the Nigerian Medical Association, River state Branch. The copyright of papers published are vested in the journal and the publisher. In line with our open access policy and the Creative Commons Attribution License policy authors are allowed to share their work with an acknowledgement of the work's authorship and initial publication in this journal.
This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author.
The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations. While the advice and information in this journal are believed to be true and accurate on the date of its going to press, neither the authors, the editors, nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein.
TNHJ also supports open access archiving of articles published in the journal after three months of publication. Authors are permitted and encouraged to post their work online (e.g, in institutional repositories or on their website) within the stated period, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). All requests for permission for open access archiving outside this period should be sent to the editor via email to editor@tnhjph.com.
