Cardiovascular Risk Factors and Renal Impairment among Young Adults in a Tertiary Institution in Southwest Nigeria

Authors

  • Akinwumi Ayodeji Akinbodewa University of Medical Sciences Teaching Hospital, Ondo State
  • Oluseyi Ademola Adejumo University of Medical Sciences Teaching Hospital, Ondo State
  • Oluwakemi Abiola Lamidi University of Medical Sciences Teaching Hospital, Ondo State
  • Ogunleye Adeyemi University of Medical Sciences Teaching Hospital, Ondo State
  • Kehinde Margareth Babatunde Hospitals Management Board, Ondo State

Keywords:

Prevalence, renal dysfunction, cardiovascular risk factors, young adults, Nigeria

Abstract

Background: Specific research is sparse on renal dysfunction among homogenous group of young adults. This study estimated the prevalence of renal dysfunction among apparently healthy young adults and determine association (if any) between renal dysfunction and some cardiovascular risk factors. 

Methodology: Undergraduates (18-37 years) of a tertiary institution were studied on 2017 World Kidney Day. Their biodata, blood pressure, anthropometry, total cholesterol and estimated glomerular filtration rate were determined. Data was analyzed using SPSS version 20.0.

Results: A total of 640 students were studied (M:F=1:3.8). Their mean age was 23.1±2.8 years. Thirty-three (5.2%) participants had renal dysfunction (eGFR < 60ml/min/1.73m2). The mean age of subjects with renal dysfunction (eGFR < 60ml/min/1.73m2) was significantly higher with an inverse association to renal function (p = 0.005). Two hundred and fifty-seven (40.2%) and 58 (9.1%) participants were pre-hypertensive and hypertensive respectively; overweight, abdominal obesity and hypercholesterolaemia were found among 12.2%, 14.2% and 8.1% of subjects respectively. The mean body mass index (p = 0.009) and serum total cholesterol (p = 0.003) were significantly higher among females. There was a higher prevalence of renal dysfunction among females even though this was not to the significant level (5.9 v 2.2%, p = 0.12).

Conclusions: The prevalence of renal dysfunction among young adults is lower than current global estimates. The prevalence of cardiovascular risk factors for CKD were lower than that of older adults with no significant association to renal dysfunction. Increasing age was found to be significantly associated with reduced renal function.  

References

Smith M. How young are “young people” and at what age does a person become “old”? Lifestyle, politics and current affairs. March 06, 2018. https://yougov.co.uk/topics/politics/articles-reports/2018/03/06/how-young-are-young-people-and-what-age-does-person-grow-old. Accessed February 22, 2019.

Adolescence: A period needing special attention. Health for the World’s adolescents report. Geneva: World Health Organization; 2014. Available at: http://apps.who.int/adolescent/second-decade/section2/page1/recognizing/adolescence.html. Accessed February 22, 2019.

United Nations General Assembly. Convention on the rights of the child. Treaty Ser 1989; 1577:3. New York, United Nations.

The Society for Adolescent Health and Medicine. Young Adult Health and Well-Being: A Position Statement of the Society for Adolescent Health and Medicine. Journal of Adolescent Health 2017;60: 758-759.

Second National Youth Policy Document of the Federal Republic of Nigeria 2009. http://www.youthpolicy.org/factsheets/country/nigeria. Accessed February 22, 2019.

Tarpenning KM, Hamilton-Wessler M, WiswellRA, Hawkins SA. Endurance training delays age of decline in leg strength and muscle morphology. Medicine and Science in Sports and Exercise. 2004;36 (1): 74-78.

Zavagnin M, Borella E, De Beni R. When the mind wanders: Age-related differences between young and older adults. Acta Psychologica 2014;145: 54–64.

Ruffman T, Sullivan S, Edge N. Differences in the way older and younger adults rate threat in faces but not situations. Journal of Gerontology: Psychological Sciences 2006;61B(4): 187–94.

Petry NM. A Comparison of young, middle-aged, and older adult treatment-seeking pathological gamblers. The Gerontologist 2002;42(1): 92–9. 9.

Rüst CA, Rosemann T, Lepers R. Age-related changes in 100-km ultra-marathon running performance. Age 2012;34 (4): 1033–45.

Halter JB, Musi N, Horne FM, Crandall JP, Goldberg A, Harkless L et al. Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions. Diabetes 2014;63: 2578–89.

Fouad M, Ismail MI, Gaballah A, Reyad E, ELdeeb S. Prevalence of obesity and risk of chronic kidney disease among young adults in Egypt. Ind J Nephrol 2016;26(6): 413-18.

Jadhakhan F, Marshall T, Ryan R, Gill P. Risk of chronic kidney disease in young adults with impaired glucose tolerance/impaired fasting glucose: a retrospective cohort study using electronic primary care records. BMC Nephrology 2018; 19:42 DOI 10.1186/s12882-018-0834-4.

Akinbodewa AA, Adejumo OA, Lamidi OA, Ogunleye O, Babatunde MK (SAT 127). Prevalence of renal dysfunction and relationship to cardiovascular risk factors among young adults in Ondo city, Southwest Nigeria (Abstract number WCN20-0182), World Congress of Nephrology 2020. Kidney International Reports 2020;5(3): S54-55.

World Health Organization. Obesity: preventing and managing the global epidemic: report of a WHO consultation. Geneva: WHO; 2000 [cited 2014 June 15]. Available from:http://www.who.int/nutrition/publications/obesity/WHO_TRS_894/en/. Accessed on February 22 2019.

World Health Organization. WHO Expert Consultation. Appropriate body mass index for Asian populations and its implications for policy and intervention strategies. 2004;363: 157–63.

Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr et al. The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure: The JNC 7 report. JAMA 2003;289: 2560-72.

Kidney Disease Improving Global Outcome (KDIGO) 2012. KDIGO 2012 clinical practice guideline of evaluation and management of CKD. Kidney Int Suppl 2013;3: 1‑150.

Meghan Dale. Trends in the age composition of College and University students and graduates. Statistics Canada. 2010. Accessed on February 22, 2019.

Coresh J, SelvinE, Stevens LA, Manzi J, Kusek JW, Eggers P et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;298(17): 2038–47.

Abd ElHafeez SA, Bolignano D, D'Arrigo G, Dounousi E, Tripepi G, Zoccali C. BMJ Open 2018;8:e015069. doi:10.1136/bmjopen-2016-015069.

Rao KVM, Reddy GPK. Prevalence of prehypertension in young adults in a semi-urban district in Telangana. Int J Adv Med. 2016;3(1): 63-7.

Kayima J, Nankabirwa J, Sinabulya I, Nakibuuka J, Zhu X, Rahman M et al. Determinants of hypertension in a young adult Ugandan population in epidemiological transition—the MEPI-CVD survey. BMC Public Health 2015;15: 830. doi: 10.1186/s12889-015-2146-y.

Widjaja FF, Santoso LA, Barus NRV, Pradana GA, Estetika C. Prehypertension and hypertension among young Indonesian adults at a primary health care in a rural area. Med J Indones. 2013;22(1): 39-45.

Grotto I, Grossman E, Huerta M, Sharabi Y. Prevalence of Prehypertension and Associated Cardiovascular Risk Profiles Among Young Israeli Adults. Hypertension. 2006;48: 254-59.

Umegbolu EI, Ogamba JO. Primary hypertension in young adults in Enugu State, south East Nigeria: a cross-sectional study. Int J Comm Med Public Health. 2016;3(10): 2825-31.

Akinbodewa AA, Adejumo AO, Koledoye OV, Kolawole JO, Akinfaderin D, Lamidi AO et al. Community screening for prehypertension, traditional risk factors and markers of chronic kidney disease in Ondo State, South-Western Nigeria. Niger Postgrad Med J 2017;24: 25-30.

Zhang Y, Moran AE. Trends in the prevalence, awareness, treatment, and control of hypertension among young adults in the United States, 1999 to 2014. Hypertension 2017;70: 736-42.

Asafa MA, Ogunlade O. Prevalence of high blood pressure among young adults in Ile Ife, Nigeria. International Journal of Analytical, Pharmaceutical and Biomedical Sciences. 2015;4(2): 69-73.

Reddy VS, Jacob GP, Ballala K, Ravi C, Ravi B, Gandhi P et al. A study on the prevalence of hypertension among young adults in a coastal district of Karnataka, South India. Int J Healthcare Biomed Res. 2015;03(03): 32-9.

Grotto I, Grossman E, Huerta M, Sharabi Y. Prevalence of Prehypertension and Associated Cardiovascular Risk Profiles Among Young Israeli Adults. Hypertension. 2006;48: 254-59.

Ostchega Y, Yoon SS, Hughes J, Louis T. National Center for Health Statistics. Hypertension awareness, treatment, and control --continued disparities in adults: United States, 2005–2006. NCHS Data Brief. 2008;3: 1-8.

Pletcher MJ, Bibbins-Domingo K, Lewis CE, Wei GS, Sidney S, Carr J. Prehypertension during Young Adulthood and Coronary Calcium Later in Life: The Coronary Artery Risk Development in Young Adults Study. Ann Intern Med. 2008; 149(2): 91–9.

Ishikawa Y, Ishikawa J, Ishikawa S, Kario K, Kajii E. Progression from prehypertension to hypertension and risk of cardiovascular disease. J Epidemiol. 2017; 27(1): 8-13.

Chinedu SN, EmilojuOC. Underweight, overweight and obesity amongst young adults in Ota, Nigeria. J Pub Health Epid 2014;6(7): 235-38.

Ukegbu PO, Uwaegbutea AC,Echendua CA, Ejike C , Anyika-Elekeha JU , Asumughaa VU. Obesity and associated factors in young adults attending tertiary institutions in southeastern Nigeria. South African Journal of Clinical Nutrition 2017; 30(2): 43–8.

Mogre V, Nyaba R, Aleyira S. Lifestyle Risk Factors of General and Abdominal Obesity in Students of the School of Medicine and Health Science of the University of Development Studies, Tamale, Ghana. ISRN Obesity Volume 2014, Article ID 508382 http://dx.doi.org/10.1155/2014/508382.

Peltzer K, Pengpid S, Samuels TA, Özcan NK, Mantilla C, Rahamefy OH. Prevalence of Overweight/Obesity and Its Associated Factors among University Students from 22 Countries Int. J. Environ. Res. Public Health 2014:11(7): 7425-41.

Thankappan KR, Shah B, Mathur P, Sarma PS, Srinivas G, Mini GK et al. Risk factor profile for chronic non-communicable diseases: results of a community-based study in Kerala, India. Indian J Med Res. 2010;131: 53–63.

National Institute of Medical Statistics, Indian Council of Medical Research. Integrated disease surveillance project (IDSP). Non-communicable disease risk factors survey. 2007–08. Phase-I states of India. New Delhi: National Institute of Medical Statistics and Division of Non-Communicable Diseases, Indian Council of Medical Research; 2009 (http://www.icmr.nic.in/final/IDSP-NCD%20Reports/Phase 1%20States%20of%20India.pdf. Accessed February 23 2019.

Okaka EI, Fiya BO. Prevalence and pattern of dyslipidaemia in a rural community in Southern Nigeria. Afr J Med Health Sci 2013; 12: 82-6.

Oguoma V, Nwose EU, Skinner TC, Digban K, Onyia IC, Richards RS. Prevalence of cardiovascular disease risk factors among a Nigerian adult population: Relationship with income level and accessibility to CVD risks screening. BMC Public Health 2015;15: 397. DOI 10. 1186/s 12889-015-1709-2.

Jungers P, Chauveau P, Descamps-Latscha B, Labrunie M, Giraud E, Man NK et al. Age and gender-

related incidence of chronic renal failure in a French urban area: a prospective epidemiologic study. Nephrol Dial Transplant. 1996;11(8): 1542-46.

Hosseinpanah F, Kasraei F, Nassiri AA, Fereidoun Azizi. High prevalence of chronic kidney disease in Iran: a large population-based study. BMC Public Health. 2009;9: 44. doi: 10.1186/1471-2458-9-44.

United States Renal Data System. 2015 USRDS annual data report: Epidemiology of kidney disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. 2015. Available at: http://www.usrds.org/adr.aspx. Accessed on February 22, 2019.

Okadaa K, Yanaia M, Takeuchia K, Matsuyama K, Nitta K, Hayashi K et al. Sex differences in the prevalence, progression, and improvement of chronic kidney disease. Kidney Blood Press Res 2014;39: 279-88.

Werner KB, Elmstahl S, Christensson A, PihlsgardM. Male sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease. Age Ageing. 2014;43(3): 411-17.

Okoye, O. C. Gender disparity in risk factors for chronic kidney disease in a rural community in Southern Nigeria. Kanem Journal of Medical Sciences; 14(1): 62-71, 2020.

Tadongfack TD, Keubo F, Bianke P. (2020). Hepatitis B infection in the rural area of Dschang, Cameroon: seroprevalence and associated factors.The Pan Afr. Med.J.2020;36:362. https://doi.org/10.11604/pamj.2020.36.362.17787

Xu Y, Liu H, Wang Y, Hao R, Li Z, Song H. The next step in controlling HBV inChina.BMJ2013;347:f4503. doi: 10.1136/bmj.f4503.

Spearman CW, Afihene M, Ally R, Apica B, Awuku Y, Cunha L et al. Hepatitis B in sub-Saharan Africa: strategies to achieve the 2030 elimination targets. The Lancet Gastroenterology & Hepatology 2017;2(12):900-909. doi:https://doi.org/10.1016/S2468-1253(17)30295-9

McMahon BJ. The natural history of chronic hepatitis B virus infection. Hepatology 2009;49(5):S45–55. doi: 10.1002/hep.22898.

Anigilaje EA, Olutola A.Prevalence and Clinical and Immunoviralogical Profile of Human Immunodeficiency Virus-Hepatitis B Coinfection among Children in an Antiretroviral Therapy Programme in Benue State, Nigeria.ISRN Pediatr2013;2013:932697. doi: 10.1155/2013/932697.

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Published

2023-01-07

How to Cite

Akinbodewa, A. A., Adejumo, O. A., Lamidi, O. A., Adeyemi, O., & Babatunde, K. M. (2023). Cardiovascular Risk Factors and Renal Impairment among Young Adults in a Tertiary Institution in Southwest Nigeria . The Nigerian Health Journal, 22(4), 348–356. Retrieved from https://tnhjph.com/index.php/tnhj/article/view/589

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