Case report of koebnerization of herpes zoster lesions by Psoriasis in a HIV positive patient

Ehiaghe Lonia Anaba


Koebner’s phenomenon (isomorphic response or isotopic response) is defined as the occurrence of a new typical skin disease at the site of another unrelated, completely different and already healed skin disease. Skin disease have been reported in Human Immune deficiency disease (HIV). These skin disease can serve as diagnostic a clues to immunosuppression, be used in the staging of HIV disease and can be multiple. Some reports of koebnerization of skin diseases in HIV have been documented.

We report the case of a 48 year old male patient, newly diagnosed with HIV disease. He also developed psoriasis and these psoriatic lesions were found on healed multi-dermatomal lesions of herpes zoster.

KEYWORDS: Köebner phenomenon, HIV, psoriasis, herpes zoster.





Parker SR. The skin and HIV: no superficial matter. Top Antivir Med. 2014;22:680-4.

Tan J, Pina A, Borges-Costa J. Skin Diseases in the Era of Highly Active Antiretroviral Therapy: A Retrospective Study of 534 Patients. J Int Assoc Provid AIDS Care. 2018;17:2325957417752255.

Oninla OA. Mucocutaneous Manifestations of HIV and the Correlation with WHO Clinical Staging in a Tertiary Hospital in Nigeria. AIDS Res.Treat.2014;doi: 10.1155/2014/360970. 6pgs

Katibi OS, Ogunbiyi AO, Oladokun RE, Ernest SK, Osinusi K, Brown BJ, Adedoyin OT, Ojuawo AI. Mucocutaneous Disorders of Pediatric HIV in South West Nigeria: Surrogates for Immunologic and Virologic Indices. J Int Assoc Provid AIDS Care. 2016;15:423-31.

Kore SD, Kanwar AJ, Vinay K, Wanchu A.. Pattern of Mucocutaneous Manifestations in Human Immunodeficiency Virus-positive Patients in North India. Indian J Sex Transm Dis. 2013;34: 19–24.

Boushab BM, Malick Fall FZ, Ould Cheikh Mohamed Vadel TK, Ould Cheikh Melaïnine ML, Maazouz MV, Savadogo M, Basco LK. Mucocutaneous manifestations in human immunodeficiency virus (HIV)-infected patients in Nouakchott, Mauritania. Int J Dermatol. 2017;56:1421-1424.

Lai S, Lin C, Liao K, Chen W. Herpes Zoster Could Be an Early Manifestation of Undiagnosed Human Immunodeficiency Virus Infection. J. Formosan Med Assoc 2016;115: 372-376.

Wu JJ, Gilbert KE, Batech M, Manalo IF, Towner WJ, Raposo RA, Nixon DF, Liao W. Examining HIV Viral Load in a Matched Cohort of HIV Positive Individuals with and without Psoriasis. J Drugs Dermatol. 2017;16:372-377.

Yen YF, Jen IA, Chen M, Lan YC, Lee CY, Chuang PH, Lee Y, Arthur Chen YM. HIV Infection Increases the Risk of Incident Psoriasis: A Nationwide Population-Based Cohort Study in Taiwan. J Acquir Immune Defic Syndr. 2017;75:493-499.

Batista KZS, Bogoni B, Müller RC, Penedo CC, da Silva Filho HH. Influence of Comorbidities on CD4+/CD8+ Proportion in HIV-Positive Patients in Blumenau, State of Santa Catarina: a Retrospective study. Rev Soc Bras Med Trop. 2017;50:666-669.

Nwako-Mohamadi, Madan V, Tanko MN, Vento S. Psoriasis in an HIV-Infected Woman on Antiretroviral Therapy IMAJ. 2014;16:262-263.

Awofala AA, Ogundele OE. HIV Epidemiology in Nigeria. Saudi Journal of Biological Sciences. 2016; j.sjbs.2016.03.006. 6.1

Nuno-Gonzalez A, Martin-Rios MD, Lopez-Estebaranz JL, Losa JE, Sanz-Navarro J, Jimena Sanz-Bueno J, Vicente-Martin J. Skin Diseases in HIV-positive Patients Treated with HAART in a Spanish Hospital. J Am Acad Dermatol 2015;1028:AB151.

Lee Y-T, Nfor ON, Tantoh DM, Huang J-Y, Ku W-Y, Hsu S-Y, Ko P-C, Hung H-C, Jan C-F, Liaw Y-P. Herpes Zoster as a Predictor of HIV Infection in Taiwan: A Population-Based Study PLoS ONE 2015;10: e0142254.

Morar N, Willis-Owen SA, Maurer T, Bunker CB. HIV-associated psoriasis: pathogenesis, clinical features, and management. Lancet Infect Dis 2010; 10: 470–78.

Menon K, Van Voorhees AB, Bebo BF, Gladman DD, Hsu S, Kalb RE, Lebwohl MG, Strober BE. Psoriasis in patients with HIV infection: From the Medical Board of the National Psoriasis Foundation. J Am Acad Dermatol 2010;62:291-9.

Wolf R, Wolf D, Ruocco E, Brunetti G, Ruocco V. Wolf's sotopic Response. Clin Dermatol.2011;29:237-40.

Happle R, Kluger N. Koebner's Sheep in Wolf's Clothing: Does the Isotopic Response Exist as a Distinct Phenomenon? J Eur Acad Dermatol Venereol. 2018;32:542-543.

Berth-Jones J. Psoriasis. Medicine. 2009;37:5:235-241.

Full Text: PDF


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

ISSN: 1597-4292