Recent Change of Locality as Risk Factor for Malaria Fever Among New Residents of Ahoada East Local Government Area in Southern Nigeria
Keywords:
Change of Locality, Malaria Risk, Semi-Immune, NigeriaAbstract
Background: Relocation which is a well-known determinant of malaria in non-immune travelers to malarious areas, has also been found to be a risk factor for malaria among semi-immune persons who change locality within endemic regions. Further research evidence suggests that the higher transmission intensity at the travel location is an underlying factor which may indicate exposure to new variants of P falciparum for which specific immunity is lacking. This study was conducted to determine if recent change of locality increased the risk of malaria fever among semi-immune National Youth Service Corps members serving in a district in southern Nigeria.
Method: Ninety six corps members who had just been posted to Ahoada-East LGA in southern Nigeria and 83 others that had been in service for six months, were followed up for malaria fever in a prospective cohort design over a 3 month period from September 2010 to December 2010. Active surveillance was used to obtain reports of fever among the cohort, followed by medical examination at designated local health facilities.
Results: No significant differences in age and use of protection against malaria were found between the study groups. The incidence proportion of malaria for the recently relocated group (34%) was significantly higher than that of the resident group (15.7%). Recent change of locality was more associated with malaria fever (RR 2.19, 95% CI 1.243.88, AR 54.4%).
Conclusion: The recent change of locality within an endemic region, which serves as an indicator of exposure to new variants of P falciparum; for which specific immunity is lacking, is a significant risk factor for malaria fever. Protection against malaria is recommended for semi-immune individuals moving to new locations with significant risk of malaria transmission.
References
World Health Organization. World Malaria Report 2008. [e-book]. Geneva. WHO Press. 2008. Available from:http://www.who.int/malaria/publications/atoz/9789241563697/en/index.html[Accessed 10th December 2009]
World Health Organization. Malaria Fact Sheet N°94 [Online]. Available from:http://www.who.int/mediacentre/factsheets/fs094/en/[Accessed10thDecember2009]
Roll Back Malaria. Key Malaria Facts [Online]. Available from:www.rollbackmalaria.org/keyfacts.html[Accessed 10th December 2009]
World Health Organization. World Malaria Report 2009. [e-book]. Geneva. WHO Press. 2009. Available from:http://www.who.int/malaria/publications/atoz/9789241563901/en/index.html[Accessed 10th December 2009]
World Health organization. WHO Global Malaria Programme: World Malaria Report 2010. World Health organization, 2010.
Shanks GD, Biomndo K, Guyatt HL, Snow RW. Travel as risk factor for uncomplicated Plasmodium falciparum malaria in the highlands of Western Kenya. Transactions of the Royal Society of Tropical Medicine and Hygiene [Online]. 2005;99: pp. 7174. Availablefrom:doi:10.1016/j.trstmh.2004.04.001. [Accessed 28th July 2009].
Shanks GD, Biomndo K, Maguire J. Travel as a Risk Factor for Malaria Requiring Hospitalization on a Highland Tea Plantation in Western Kenya. Journal of Travel Medicine [Online] 2004;11(6): pp. 354358. Available from: DOI:10.2310/7060.2004.19203. [Accessed 28th July 2009]
Osorio L, Todd J, Bradley DJ. Travel Histories as Risk Factor in the Analysis of Urban Malaria in Columbia. American Journal of Tropical Medicine & Hygiene [Online].2004;71(4):pp.380386.Availablefrom:http://hinari-gw.who.int/whalecomwww.ajtmh.org/whalecom0/cgi/content/full/71/4/380 [Accessed 28th July 2009].
Marsh K. Immunology of malaria, In: Warrell DA, Gilles HM (eds.). Essential Malariology.4thed.London:HodderArnold; 2002. p. 257.
BabikerHA,CreaseyAM,FentonB,Bayoumi RA, Arnot DE, Walliker D. Genetic diversity of Plasmodium falciparum in a village in eastern Sudan. 1. Diversity of enzymes, 2D-PAGE proteins and antigens. TransactionsoftheRoyalSocietyofTropical Medicine & Hygiene [Online] 1991;85(5): pp. 572-7. Available from: http://www.tropicalmedandhygienejrnl.net/article/0035-9203(91)90347-2/abstract[Accessed 22nd January 2010].
Hoffmann EH, da Silveira LA, Tonhosolo R, PereiraFJ,RibeiroWL,TononAP,Kawamoto F, Ferreira MU. Geographical patternsofallelicdiversityinthePlasmodium falciparum malaria-vaccine candidate, merozoite surface protein-2. AnnalsofTropicalMedicineandParasitology [Online] 2001;95(2): pp. 117-132. Available from: DOI:10.1080/00034980120045833[Accessed21st January 2010].
Henry M, Diallo I, Bordes J, Ka S, Pradines B, Diatta B, M'Baye PS, Sane M, Thiam M, Gueye PM, Wade B, Touze JE, Debonne JM, Rogier C, Fusai T. Urban malaria in Dakar, Senegal: chemosusceptibility and genetic diversityofPlasmodiumfalciparumisolates. American Journal of Tropical medicineandHygiene[Online]2006;75(1): pp. 146-51. Available from:http://hinarigw.who.int/whalecomwww.ajtmh.org/whalecom0/cgi/content/full/75/1/146 [Accessed 21st January 2010].
Basco LK, Tahar R, Escalante A. Molecular epidemiology of malaria in Cameroon. XVIII. Polymorphisms of the Plasmodium falciparum merozoite surface antigen-2 gene in isolates from symptomatic patients. American Journal of Tropical Medicine and Hygiene [Online] 2004;70(3): pp. 238-44. Availablefrom:http://hinarigw.who.int/whalecomwww.ajtmh.org/whalecom0/cgi/content/full/70/3/238 [Accessed 21st January 2010].
Aubouy A, Migot-Nabias F, Deloron P. Polymorphism in two merozoite surface proteins of Plasmodium falciparum isolates from Gabon. Malaria Journal [Online] 2003;2:p.12.Availablefrom:doi:10.1186/1475-2875-2-12[Accessed21st January 2010].
Felger I, Tavul L, Kabintik S, Marshall V, Genton B, Alpers M, Beck HP. Plasmodium falciparum: extensive polymorphism in merozoite surface antigen 2 alleles in an area with endemic malaria in Papua New Guinea. Experimental Parasitology [Online] 1994;79(2): pp. 106-16. Available from:doi:10.1006/expr.1994.1070[Accessed 21st January 2010].
Happi CT, Gbotosho GO, Sowunmi A, Falade CO, Akinboye DO, Gerena L, Kyle DE, Milhous W, Wirth DF, Oduola AM. MolecularanalysisofPlasmodiumfalciparum recrudescent malaria infections in children treated with chloroquine in Nigeria. The American Journal of Tropical MedicineandHygiene[Online]2004;70(1): pp. 20-6. Available from: http://hinarigw.who.int/whalecomwww.ajtmh.org/whalecom0/cgi/content/full/70/1/20 [Accessed 21st January 2010].
KiwanukaGN.GeneticdiversityinPlasmodium falciparum merozoite surface protein 1 and 2 coding genes and its implications in malaria epidemiology: a review of published studies from 1997-2007. Journal of Vector Borne Diseases [Online] 2009;46(1): pp. 1-12. Available from:http://www.ncbi.nlm.nih.gov/sites/entrez[Accessed 22nd January].
Doolan DL, Dobaño C, Baird JK. Acquired immunity to malaria. Clinical Microbiology Reviews 2009;22(1): pp. 13-36. Available from:doi:10.1128/CMR.00025-08[Accessed 10th February 2010].
Cavanagh DR, Elhassan IM, Roper C, Robinson VJ, Giha H, Holder AA, Hviid L, Theander TG, Arnot DE, McBride JS. A longitudinal study of type-specific antibody responsestoPlasmodiumfalciparummerozoite surface protein-1 in an area of unstable malaria in Sudan. The Journal of Immunology [Online] 1998;161: pp. 347-359.Availablefrom:http://www.jimmunol.org/cgi/content/full/161/1/347 [Accessed 10th February 2010].
Chattopadhyay R, Sharma A, Srivastava VK, Pati SS, Sharma SK, Das BS, Chitnis CE. Plasmodium falciparum Infection Elicits Both Variant-Specific and Cross-Reactive Antibodies against Variant Surface Antigens. Infectious Immunology [Online] 2003;71(2): pp. 597604. Available from: doi:10.1128/IAI.71.2.597-604.2003.[Accessed 30th July 2009].
Mamillapalli A, Sunil S, Diwan SS, Sharma SK, Tyagi PK, Adak T, Joshi H, Malhotra P. Polymorphism and epitope sharing between the alleles of merozoite surface protein-1ofPlasmodiumfalciparumamong Indian isolates. Malaria Journal [Online] 2007;6: p. 95. Available from: doi: 10.1186/1475-2875-6-95 [Accessed 30th July 2009].
SindenRE,GillesHM.Themalariaparasites, In: Warrell DA, Gilles HM (eds.) Essential malariology. 4th ed. London: Hodder Arnold; 2002. P.8,27-28.
HaddadD,SnounouG,MatteiD,Enamorado IG, Figueroa J, Stahl S, Berzins K. Limited genetic diversity of Plasmodium falciparum in field isolates from Honduras. American Journal of Tropical Medicine and Hygiene [Online] 1999;60(1): pp. 30-4. Availablefrom:http://hinarigw.who.int/whalecomwww.ajtmh.org/whalecom0/cgi/reprint/60/1/30[Accessed 21st January 2010].
Babiker HA, Satti G, Walliker D. Genetic changes in the population of Plasmodium falciparum in a Sudanese village over a three-year period. American Journal of Tropical Medicine and Hygiene [Online] 1995;53(1): pp. 7-15. Available from:http://hinarigw.who.int/whalecomwww.ajtmh.org/whalecom0/cgi/reprint/53/1/7[Accessed 21st January 2010].
RanjitMR,SharmaYD.Geneticpolymorphismoffalciparummalariavaccine candidate antigen genes among field isolates in India. American Journal of Tropical Medicine and Hygiene [Online] 1999;61(1): pp. 103-108. Available from:http://hinarigw.who.int/whalecomwww.ajtmh.org/whalecom0/cgi/reprint/61/1/103[Accessed 21st January 2010].
Soulama I, Nébié I, Ouédraogo A, Gansane A, Diarra A, Tiono AB, Bougouma EC, Konaté AT, Kabré GB, Taylor WR, Sirima SB. Plasmodium falciparum genotypes diversityinsymptomaticmalariaofchildren living in an urban and a rural setting in Burkina Faso. Malaria Journal [Online] 2009; 8: p. 135. Available from: doi: 10.1186/1475-2875-8-135. [Accessed 10th February 2010].
Segerstrom SC, Miller GE. Psychological Stress and the Human Immune System: A Meta-Analytic Study of 30 Years of Inquiry. PsychologicalBulletin[Online].2004;130(4): pp. 601630. Available from: DOI:10.1037/0033-2909.130.4.601.[Accessed 10th December 2009].
Mayor A, Aponte JJ, Fogg C, Saute F, Greenwood B, Dgedge M, Menendez C, Alonso PL. The epidemiology of malaria in adultsinaruralareaofsouthernMozambique. Malaria Journal [Online] 2007;6:3.Availablefrom:doi:10.1186/1475-2875-6-3[Accessed12th August 2010].
Snow RW, Gilles HM. The epidemiology of malaria, In: Warrell DA, Gilles HM (eds.) Essential malariology. 4th ed. London: Hodder Arnold; 2002. p. 95,100.
Anumudu CI, Adepoju A, Adeniran M, Adeoye O, Kassim A, Oyewole I, Nwuba RI. Malaria prevalence and treatment seeking behaviour of young Nigerian adults. Annals of African Medicine [Online] 2006;5:2 . pp. 82-88. Available from:http://www.ajol.info/index.php/aam/article/viewFile/8380/13982[Accessed12th
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